Objective: To study the intervention effect of Qiangxin Huoli recipe on cardiotoxicity after chemotherapy of antitumor drug ADR in rats. Method: Totally 96 healthy Wistar rats were randomly divided into 6 groups

namely normal group

ADR model group (16 mg·kg-1)

Shenfu control group (3 g·kg-1)

and high-dose

medium-dose

low-dose Qiangxin Huoli recipe groups (3.6

1.8

0.9 g·kg-1). The mental state

eating

feces and fur of each group of rats were observed. After 24 h of the last intragastric administration

plasma brain natriuretic peptide (BNP) levels

electrocardiogram (ECG)

whole heart mass index (HW/BW)

hematoxylin-eosin staining (HE) staining

Masson staining and transmission electron microscopy (TEM) were detected

and the myocardial morphological and ultrastructural changes were observed. Result: Compared with normal group

the ADR model group had significant differences from normal control rats (P<0.05

P<0.01) in weight loss; ECG showed significantly abnormal changes; plasma BNP and HW/BW significantly increased. Myocardial and ultrastructure injury were observed by light microscope and sem. Qiangxin Huoli recipe can obviously improve the general conditions and body quality of rats

decrease the plasma BNP levels and HW/BW

reverse the abnormal ECG

and inhibit the myocardial fibrosis

cellular edema and abnormal changes of ultrastructure

especially in the high-dose group. The differences from ADR group were quite obvious (P<0.05

P<0.01). Conclusion: Qiangxin Huoli recipe has a protective effect on adriamycin-induced cardiotoxicity in rats.