Objective: To analysis the pathogenesis and the medication regularity of consciousness diseases in prescription book Sheng Ji Zong Lu·Zhufengmen. Method: With Sheng Ji Zong Lu·Zhufengmen as the theoretical foundation

the pathogenic factors and pathogenesis of consciousness diseases were analyzed; the medication regularity in prescriptions for consciousness diseases was summarized through the software of traditional Chinese medicine (TCM) inheritance assistant system. Result: The top three drug categories by use frequency are deficiency-nourishing drugs

spirit-quieting drugs and drugs for relieving exterior syndrome. Top 11 high-frequency drugs were Ginseng Radix et Rhizoma

Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle

Poria

Saposhnikoviae Radix

Polygalae Radix

Cinnabaris

Cinnamomi Ramulus

Bovis Calculus

Fushen

Moschus

Borneolum Syntheticum. Commonly combined herbs included Ginseng Radix et Rhizoma combined with Fushen

Poria

Polygalae Radix

Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle; Cinnabaris combined with Moschus

Borneolum Syntheticum

Bovis Calculus. Conclusion: Deficiency of five internal organs and exogenous pathogenic wind are the core of consciousness disease pathogenesis. Ginseng Radix et Rhizoma could be used as the preferred drug for the treatment of tranquilizing and sedating the mind. Ginseng Radix et Rhizoma combined with Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle

Poria

Polygalae Radix can tonify the five organs

tranquilize the mind and promote the intelligence. Cinnamomi Ramulus combined with Zingiberis can tonify and smooth liver Qi. Saposhnikoviae Radix can dispel wind pathogens and smooth liver Qi. Cinnabaris combined with Moschus

Borneolum Syntheticum and Bovis Calculus can induce resuscitation and stay awake.