采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响

张慧; 高岩; 熊慧; 薛雪; 刘梦楠; 刘欢; 张颖; 李向日

doi:10.13422/j.cnki.syfjx.20181103

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采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响

药剂与炮制 | 更新时间：2024-01-04

- 采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响
- Comparison of Effect of Water Grinding,Water Washing and Grinding on Quality of Realgar by Scanning Electron Microscopy-energy Dispersive Spectrometer
- 中国实验方剂学杂志 2018年24卷第11期页码：22-26
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家公益性行业科研专项（2015070042）
- DOI：10.13422/j.cnki.syfjx.20181103
  中图分类号： R283
- 纸质出版日期：2018
- 稿件说明：
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张慧, 高岩, 熊慧, 等. 采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响[J]. 中国实验方剂学杂志, 2018,24(11):22-26.

ZHANG Hui, GAO Yan, XIONG Hui, et al. Comparison of Effect of Water Grinding,Water Washing and Grinding on Quality of Realgar by Scanning Electron Microscopy-energy Dispersive Spectrometer[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(11): 22-26.
张慧, 高岩, 熊慧, 等. 采用扫描电镜-能谱仪比较水飞法、水洗法及干研法对雄黄饮片质量的影响[J]. 中国实验方剂学杂志, 2018,24(11):22-26. DOI： 10.13422/j.cnki.syfjx.20181103.

ZHANG Hui, GAO Yan, XIONG Hui, et al. Comparison of Effect of Water Grinding,Water Washing and Grinding on Quality of Realgar by Scanning Electron Microscopy-energy Dispersive Spectrometer[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(11): 22-26. DOI： 10.13422/j.cnki.syfjx.20181103.

摘要

目的：比较雄黄水飞品、水洗品及干研品中二硫化二砷及各元素的含量，以阐明水飞法、水洗法及干研法对雄黄饮片质量的影响，并对雄黄水飞品、水洗品及干研品进行快速鉴别。方法：依据2015年版《中国药典》（一部）雄黄项下规定对3种炮制品进行含量测定；采用扫描电镜-能谱仪对雄黄3种炮制品进行形貌观察，对3种炮制品中的元素种类及含量进行分析。结果：3种炮制品的二硫化二砷含量排序为水飞品 > 水洗品 > 干研品；水飞品及水洗品的形貌相似，而干研品的形貌与其他2种炮制品不同；3种炮制品的氧元素含量排序呈现干研品 > 水洗品 > 水飞品的趋势。结论：采用扫描电镜-能谱仪可以对雄黄水飞品和干研品进行快速鉴别，为鉴别雄黄不同炮制品提供了一定的技术支持。水飞法的除杂减毒效果最好，水飞品质量优于水洗品和干研品，说明水飞法炮制雄黄具有一定的科学依据。

Abstract

Objective: To explain the effect of water grinding

water washing and grinding on the quality of Realgar by comparing the contents of As2S2 and elements in different processed products.At the same time

to identify water grinding products

water washing products and grinding products rapidly. Method: To determine the content of As2S2 in different processed products of Realgar by the method in the 2015 edition of Chinese Pharmacopoeia.Scanning electron microscopy-energy dispersive spectrometer (SEM-EDS) was used to observe the surface morphology of different processed products and determine the contents of elements in different processed products. Result: The content of As2S2 in different processed products ranked as water grinding products > water washing products > grinding products.The surface morphology of water grinding products was similar to the surface morphology of water washing products

but the surface morphology of grinding products was different from theirs.The content of oxygen in different processed products showed the trend of grinding products > water washing products > water grinding products. Conclusion: It can be distinguished between water grinding products and grinding products by SEM-EDS

it provides a certain technical support for the identification of different processed products of Realgar.The effect of water grinding on removing impurities and reducing the toxicity is best

quality of water grinding products is better than the quality of water washing products and grinding products

which shows that water grinding for Realgar has scientific basis.

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