Objective: To investigate the efficacy and mechanism of modified Da Dingfengzhu therapy combined with western medicine in the treatment of patients with Yin deficiency in liver and kidney type Parkinson's disease (PD) with pain. Method: The 96 patients with Yin deficiency in liver and kidney type PD with pain were randomly divided into control group and experimental group

48 cases in each group. All patients were given with dopasil hydrazine tablets treatment. On the basis of the treatment

the control group also received compound sea cucumber capsule

while the experimental group received modified Da Dingfengzhu therapy for 4 weeks. The clinical efficacy

motor symptoms

quality of life

emotional status

mental status and cognitive status

the plasma homocysteine (Hcy) and oxidative stress related indicators

motor nerve conduction velocity (MCV)

latency (LP) and amplitude (Amp) of the common peroneal nerve

the levels of recombinant human Parkinson's disease protein 7 (PARK7) and neurotrophic factor-3 (NT-3) before and after treatment were compared between two groups. Result: The total effective rate of the experimental group was significantly higher than that of control group (P<0.05). After treatment

the motor symptoms in experimental group were significantly better than those before treatment and control group (P<0.05). The visual analogue scale (VAS) score

39-item PD Questionnaire (PDQ-39) and unified PD rating scale (UPDRS) scores in the experimental group were significantly lower than those before treatment and control group (P<0.05). The levels of Hcy and oxidative stress in experimental group were significantly lower than those before treatment and those in control group (P<0.05). The levels of antioxidant

Amp and MCV in the experimental group were significantly higher while the LP level was significantly lower than those in control group and those before treatment (P<0.05). After treatment

the level of serum PARK7 in the experimental group was significantly lower and the level of NT-3 was significantly higher than that before treatment and that in control group (P<0.05). Conclusion: Modified Da Dingfengzhu therapy combined with western medicine can significantly improve the pain

repair nerve function

and improve the quality of life for patients in the treatment of PD with pain

and its mechanism may be related with the inhibition of excessive oxidative stress in patients.