Objective: To observe the clinical efficacy of modified Yinpu Sini Simiao Shixiao palvis on long-term sequelae of pelvic inflammatory disease (SPID) with damp heat stasis syndrome

and its regulatory effect on immune inflammatory factors. Method: One hundred and thirty-two patients with SPID were randomly divided into control group and observation group by random number table. Both groups’ patients got Pengyanqing enema at night since the third day after the end of menstruation

for successively 10 days. Patients in control group got Fuke Qianjin capsule

2 grains/time

3 times/days. Patients in observation group got modified Yinpu Sini Simiao Shixiao palvis

1 dose/day. The treatment lasted for 3 menstrual cycles

and discontinued during the menstrual period. Before and after treatment

the damp-heat stasis syndrome and pelvic signs were scored

and the quality of life was evaluated. Levels of T lymphocyte subsets (CD3+

CD4+

CD8+and CD4+/CD8+)

interleukin-2 (IL-2)

IL-4

IL-6

IL-10 and tumor necrosis factor-α (TNF-α) were detected. Result: The scores of damp-heat stasis syndrome and pelvic signs in observation group were lower than those in control group (P<0.01). And the score at all dimensions and the total score of life scale in observation group were higher than those in control group (P<0.01). Levels of CD4+ and CD4+/CD8+

IL-2

IL-4 and IL-10 in observation group were higher than those in control group (P<0.05

P<0.01)

and levels of IL-6

IL-8 and TNF-α in observation group were lower than those in control group (P<0.01). The total effective rate in observation group was 95.16%

which was higher than 83.33% in control group (χ2=4.481

P<0.05). Conclusion: In addition to retention enema with Chinese medicine

modified Yinpu Sini Simiao Shixiao palvis is also given to relieve symptoms and signs

improve the quality of life and immunity of the patients

and regulate immune inflammatory factors.