Objective: To explore the composition principles of ‘Xinrun(heat-moisturizing)’ treatment containing Angelicae Sinensis Radix or Chuanxiong Rhizoma based on the ‘Xinrun’ theory value of Danggui Shaoyaosan. Method: Formulas containing Angelicae Sinensis Radix or Chuanxiong Rhizoma related to ‘Xinrun’ treatment in the Chinese Prescription Database were collected. With the R language and R-studio software

the methods of data-mining including association rules and Apriori algorithm were used to extract and analyze the frequency of single medicine

the frequency of drug combination

and the association rules in core drug combinations. Result: A total of 91 ‘Xinrun’ formulas about Chuanxiong Rhizoma were included

and 22 core drug compositions and 19 association rules were obtained

15 association rules of which had a confidence of 1

while the lift of 4 rules (Paeoniae Radix Alba=>Angelicae Sinensis Radix

Chuanxiong Rhizoma and Paeoniae Radix Alba=>Angelicae Sinensis Radix

Poria=>Angelicae Sinensis Radix

and Chuanxiong Rhizoma and Poria=>Angelicae Sinensis Radix) was greater than 1.A total of 284 ‘Xinrun’ formulas about Angelicae Sinensis Radix were found

and 25 core drug compositions and 19 rules were obtained

all of which had a confidence of 1.Herbs used in high frequency included blood conditioning medicine

Qi supplementing medicine

heat clearing medicine

wind expelling medicine

and Qi regulating medicine. Core drug combinations contained ‘Chuanxiong Rhizoma-Angelicae Sinensis Radix’ (74%)

‘Chuanxiong Rhizoma-Glycyrrhizae Radix et Rhizoma’ (55%)

‘Chuanxiong Rhizoma-Paeoniae Radix Alba’ (48%)

‘Angelicae Sinensis Radix-Glycyrrhizae Radix et Rhizoma’ (46%)

‘Angelicae Sinensis Radix-Paeoniae Radix Alba’ (42%)

and ‘Angelicae Sinensis Radix-Rehmanniae Radix’ (36%). Angelicae Sinensis Radix

Chuanxiong Rhizoma

Paeoniae Radix Alba

Glycyrrhizae Radix et Rhizomacompatibilities were common in core drug combinations with high support degree. Conclusion: Based on the ‘Xinrun’ formulas

Angelicae Sinensis Radix or Chuanxiong Rhizoma were most frequently used with medicines which tonify the liver and kidney or soothe the liver and blood

often compatible with the medicines which tonify Qi and invigorate the spleen or expel the wind

indicating that the composition principles of ‘Xinrun’ treatment was based on the method of helping the body fluid flow indirectly. The core composition principles were basically the same with the compatibility characteristics of Danggui Shaoyaosan.