Objective: To study the toxicity reducing and efficacy enhancing effect of Shengfu injection combined with Tanreqing injection on chemotherapy by supplementing Qi

warming Yang

resolving phlegm and detoxicating in elderly patients with advanced stage non-small cell lung cancer (NSCLC) of the wild type epithelial growth factor receptor(EGFR)after docetaxel chemotherapy. Method: The 64 eligible patients were divided into 2 groups equally:control group (docetaxel single drug chemotherapy regimen) and treatment group (Chinese medicine regimen with supplementing Qi

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resolving phlegm and detoxicating effect based on the treatment in control group). All patients were injected with Docetaxel of 75 mg·m-2 by drip of each cycle in first day

and the patients in treatment group additionally received traditional Chinese medicine (TCM) regimen of Supplementing Qi

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and detoxification effect (60-80 mL Shengfu injection was added to 250 mL 5% glucose injection for intravenous drip

qd

and 20-30 mL Tanreqing injection was added to 250 mL 5% glucose injection 250 mL

qd). The TCM regimen was given for 10 days. 21 days were regarded as 1 cycle

and the symptoms of Chinese medicine

immunologic function

Ⅲ-Ⅳ bone marrow suppression and safety were evaluated after 2 cycles' treatment. Result: The improvement of TCM symptoms (weak breath

hemoptysis

cough

expectorating phlegm

chest pain

chest tightness

et al) in the treatment group was better than that in control group

and the difference was statistically significant (P<0.05). After treatment

the peripheral blood CD3+

CD4+ and interleukin (IL)-27 of the treatment group were higher than those of control group (P<0.05)

and CD8+ and cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) were lower than those of the control group (P<0.05)

with statistically significant difference (P<0.05). As compared with control group

the treatment group had a lower hematologic toxicity of grade Ⅲ/Ⅳ (P<0.05). Conclusion: Shengfu injection combined with Tanreqing injection with supplementing Qi

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resolving phlegm and detoxicating effect can improve the TCM symptoms of advanced non-small cell lung cancer in elderly patients

increased the immune function of patients after chemotherapy

reduce the toxicity of hematology

with high safety

toxicity reducing and efficacy enhancing effect

so it is worthy of clinical application.