To review the studies on clinical application and functionary mechanism of Zhengan Xifeng Tang in treatment of primary hypertension in recent years. Zhengan Xifeng Tang was a classical famous prescription created by ZHANG Xi-chun in Qing dynasty for treatment of stroke

which is also commonly used in the clinical treatment of primary hypertension in modern medicine. According to Records of Tradition Chinese and Western Medicine in Combination

Zhengan Xifeng Tang has the effect of stopping endogenous wind

nourishing yin to suppress Yang

with a good effect on primary hypertension. The mechanism of hypertension is complex

so although there are so many types of drugs for the treatment of essential hypertension

modern western medicine still has such problems as single target and many adverse reactions. The therapeutic characteristics of Chinese medicine compound of multiple targets and pathways

play a unique advantage in reducing the adverse reactions and improving the symptoms of hypertensive patients. At present

there are many researches on treatment of primary hypertension with Zhengan Xifeng Tang

achieving certain progress from the clinical practice of traditional Chinese medicine to experimental research

especially the new viewpoint of gastrointestinal hormone has enriched the theory of hypertension mechanism. However

the researches on the therapeutic approach and target target in the treatment of hypertension still need to be further studied. According to the literature at home and abroad about clinical application and mechanism of Zhengan Xifeng Tang in treatment of primary hypertension

it was found that its mechanism mainly involved the following aspects:regulating gastrointestinal hormones

improving vascular endothelial function

improving vascular remodeling

blocking the renin-angiotensin-aldosterone system (RAAS)

regulating blood lipid

depressing sympathetic nerves

improving insulin resistance and intervening ion channel of cell membrane. Based on the hypotensive effect of Zhengan Xifeng Tang in many ways and multiple targets and mainly from the pathogenesis and pathophysiological changes of primary hypertension

this paper provided a new strategy for the treatment of primary hypertension with traditional Chinese medicine.