Objective: To observe the effect of Jinlan granule on acute pharyngitis induced by Coxsackie virus

adenovirus

and influenza virus infection in infancy rabbits and infancy mice. Method: Totally 48 infancy rabbits were randomly divided into normal group

model group

Ribavirin group (22.5 mg·kg-1·d-1)

Xiaoer Qingyan group (2.7 g·kg-1·d-1)

Jinlan granule double dose group

equal dose group

1/2 dose group

and 1/3 dose group (2.18

1.09

0.55

0.36 g·kg-1·d-1)

n=6 in each group. Acute pharyngitis model in infancy rabbits was induced by Coxsackie B4 virus infection

and then Jinlan granule was successively administered daily for 3 days beginning from the day of infection. After that

pharynx tissue was taken for pathological examination. Infancy mice were infected by adenovirus successively for 3 times to induce acute pharyngitis model in infancy mice

and then Jinlan granule was successively administered daily for 3 days beginning from the day of infection. After that

pharyngeal mucosa was taken to observe pathological changes. After infancy mice were infected by influenza virus

the number of mice death in the 2 weeks after infection was observed. Result: As compared with normal group

pharyngeal tissues of rabbits showed obvious pathological changes after infection with coxsackie virus; as compared with the model group

Jinlan granule at 4 different doses could significantly relieve the pathological changes of pharyngeal tissues. As compared with the normal group

pharyngeal tissues of mice showed obvious pathological changes after infection with adenovirus

and were significantly relieved by Jinlan granule at doses of 6.48

3.24

1.62

1.08 g·kg-1·d-1. Conclusion: Jinlan granule has significant inhibitory effect on acute pharyngitis induced by coxsackie virus and adenovirus in infancy rabbits and mice respectively.