Objective: To observe the efficacy of modified Dingzhenwan combined with acupuncture method of consciousness restoration and resuscitation in treating patients with Parkinson's disease (PD)

and investigate its possible mechanism. Method: Eighty-two patients with PD were chosen and randomly divided into control group (41 cases) and treatment group (41 cases) referring to random number table. Both groups orally took levodopa/benserazide dispersible tablet

0.125 g/time

tid. The patients in control group were additionally treated with acupuncture method of consciousness restoration and resuscitation

1 time/day and 6 times/week. On basis of the treatment in control group

the patients in treatment group were additionally treated with Dingzhenwan

1 dose/day and bid. Both groups were treated for 8 weeks. Then the scores of dysfunction of tremor syndrome

symptoms of liver and kidney Yin deficiency syndrome

the Unified PD Rating Scale (UPDRS)

non-motor symptoms questionnaire for Parkinson's disease (NMSQuest)

Parkinson's non-motor symptom rating scale (NMSS) and clinical efficacy were compared between two groups. Serum levels of B cell lymphoma/leukemia 2 (Bcl-2)

Bcl-associated X protein (Bax)

cytochrome C (CytC)

Caspase-9

Caspase-3 and Caspase-6 were detected and compared between these two groups. Result: After treatment

the scores of dysfunction of tremor syndrome

symptoms of liver and kidney deficiency syndrome

UPDRS-Ⅰ

UPDRS-Ⅱand UPDRS-Ⅲ in treatment group were significantly lower than those in control group (P<0.01). As compared to the control group

scores of NMSQuest and NMSS were obviously decreased in treatment group after treatment (P<0.01). Total effective rate was 87.8% in treatment group

higher than 65.85% in control group (P<0.05). After treatment

serum level of Bcl-2 in treatment group was significantly higher

while Bax

Cytc

Caspase-9

Caspase-3 and Caspase-6 levels were significantly lower than those in control group (P<0.01). Conclusion: Based on routine western medicine

Dingzhenwan combined with acupuncture method of consciousness restoration and resuscitation has significant efficacy in treating PD

and the mechanism may be associated with regulating Bcl-2

Bax and CytC levels and inhibiting Caspase-9

Caspase-3 and Caspase-6 levels.