Due to the limitation of metastatic inhibitory therapies

metastasis has become the main cause of cancerous death clinically. Currently

increasing evidences have proved that the tumor cell-induced platelet aggregation (TCIPA) is the basis model for the interaction of metastatic tumor cells and platelets. By disturbing the physiological coagulation balance and maintaining the bidirectional pro-tumoral properties in hemato-microenvironment

TCIPA also functionally determines a series of crucial cascades for metastasis. On one hand

the formation of platelet aggregates surrounding tumor cells supports their survival and protects them against host immuno-elimination; on the other hand

activated platelets could in turn promote the tumor cell transportation along the bloodstream and finally enhance the colony formation within the distant organs. Spatholobi Caulis is a kind of classic traditional Chinese medicines of promoting blood circulation to remove blood stasis. Its effect in improving the hypercoagulable state has been recorded in lots of ancient Chinese medical books. In recent years

more and more reports have shown that it plays a key role in anti-tumor metastasis by regulating the blood microenvironment. In light of this

our review summarized the pathological characteristics and the regulation mechanism of platelet-tumor interaction. Additionally

we also discussed the potential value of anti-platelet drugs represented by Spatholobi Caulis

in order to provide the comprehensive anti-metastatic strategy. We wrote this review to highlight the significance and the systematic recognition of anti-TCIPA therapy. Moreover

we would provide a direction for the research and development of anti-metastatic drugs in the future.