Hepatic fibrosis is the common pathological feature in almost all patients with chronic liver injury

which leads to cirrhosis gradually. Though many kinds of drugs can be used to treat hepatic fibrosis diseases

western medicines are limited to treat hepatic fibrosis

because of their single target and plentiful adverse reactions. And the mechanisms and active ingredients of most traditional Chinese medicines are not clear

with no uniform diagnosis and treatment standard. Therefore

it is essential to find an effective anti hepatic fibrosis drug with a clear material basis. Due to the structural diversity

less side effects and abundant resources

products from natural resources have unique advantages and a good potential in treatment of hepatic fibrosis. This article reviews the natural products with the effect of anti-liver fibrosis

including alkaloids

polysaccharides

flavonoids

polypeptides

terpenes and phenols

retrieved through CNKI

Sciencedirect

Xueshu.baidu.com and other databases. Besides

it also summarizes the anti-hepatic fibrosis mechanisms

including inhibiting inflammation of liver

resisting lipid peroxidation

inhibiting hepatic stellate cell activation and proliferation

impacting synthesis and secretion of profibrotic cytokines

and regulating synthesis and degradation of extracellular matrix

in order to provide a reference for the development of anti-hepatic fibrosis drugs.