Objective: To discuss the efficacy of addition and subtracton of Xiaobanyin on facial hormone-dependent dermatitis (HDD) and its effect on helper T cells immune inflammation and skin barrier function. Method: One hundred and nineteen patients with HDD were randomly divided into control group 59 cases and observation group 60 cases by random number table and hierarchical block designs. Patients in control group were given loratadine tablets

10 mg/time

1 time/day. And hydroxychloroquine sulfate tablets

0.2 g/time

2 times/days. In addition to the therapy of control group

patients in observation group were also given addition and subtracton of Xiaobanyin

1 dose/day. A course of treatment was 8 weeks. Before and after treatment

scores of subjective symptoms and objective skin injury were recorded. Skin barrier function

interferon-γ (IFN-γ)

interleukin-2(IL-2)

IL-4

IL-6

IL-10

IL-1

IL-13 and tumor necrosis factor-α (TNF-α) were detected. And dermatology life quality index (DLQI) was evaluated. Result: The total effect rate in observation group was 93.33%

which was higher than 79.66% in control group (χ2=4.778

P<0.05). Score of symptom in observation group was lower than that in control group (P<0.01). Water content of corneum and sebum in observation group were higher than those in control group

while transepidermal water loss was less than that in control group (P<0.01). And levels of IFN-γ and IL-2 were higher than those in control group

whereas levels of IL-4

IL-6

IL-10

IL-1

IL-13

TNF-α scores of DLQI and the total score were lower than those in control group (P<0.01). Conclusion: In addition to the therapy of western medicine treatment

addition and subtracton of Xiaobanyin can relieve the symptom of HDD and inflammatory injury

improve the quality of life and the clinical effect

regulate levels of Th1/Th2 cytokines and promote the recovery of skin barrier function.