Objective: To establish a method for simultaneous determination of 192 kinds of pesticide residues in ginseng by using gas and liquid chromatography tandem mass spectrometry (GC-MS/MS)

and determine 11 batches of ginseng samples(including Panacis Quinquefolii Radix

Ginseng Radix et Rhizoma

Ginseng Radix et Rhizoma Rubra and white ginseng). Method: The 192 types of pesticides commonly used in ginseng planting

forbidden in agriculture planting and those with high toxicity were selected as the detecting indexes in this method according to the risk control principals. The samples were extracted with acetonitrile

and the quantitative analysis was carried out by GC-MS/MS with multiple reaction monitoring (MRM) model. The analyte protectant-internal standard method was used to improve the accuracy of this method. The extraction solvents

purification methods (including solid phase extraction and Quechers)

and the conditions of chromatography-mass spectrometry were investigated and optimized. Result: The experimental results showed that the liner range for 192 pesticides were in the range of 1-100 μg·L-1 with correction coefficients of greater than 0.99.The average recoveries of 98% pesticides ranged from 70% to 120% at levels of 5

20

and 100 μg·kg-1. 14 kinds of pesticide monomers were detected in 11 batches of ginseng samples

and the detection rate of pentachloro-nitrobenzene(PCNB)was highest. According to the pesticide maximum residual limit(MRL)of ginseng and Panax quinquefolium in 2015 Chinese Pharmacopoeia

36% of the samples exceeded the MRL. Conclusion: This method has been proven accurate

quick

sensitive and suitable for determination of 192 pesticide residues in ginseng.