Huoxue powder is a proved recipe of Mr. Du Zi-ming

a famous veteran doctor of traditional Chinese medicine(TCM) at Guang'anmen Hospital. The main effect is to warm channels to dispel cold dampness

promote blood circulation and relieve pain. In clinic

it is widely applied in treating knee osteoarthritis (KOA) and other relevant diseases

with a good efficacy. Notopterygii Rhizoma et Radix-Angelicae Pubescentis Radix are commonly used drugs for the treatment of osteoarthritis of the knee

and important components of Huoxue powder. With Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix as the key words

the authors retrieved relevant research literatures over the past ten years

and retain the literatures related to this article. The clinical and pharmacological studies of Notopterygii Rhizoma et Radix-Angelicae Pubescentis Radix were reviewed and summarized for analysis. According to the summary and analysis of the literatures

① Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix can dispel wind and dehumidification

warm meridian and relieve cold and relieve pain

and are effective drugs for the treatment of osteoarthritis of knee. The total effective rate of clinical treatment was above 80%

and the curative effect was remarkable. ② The combined application of Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix could help enhance the efficacy

so the clinical efficacy was significantly higher than the single application. The cause may be related to the changes in volatile oil

such as the increase in species and number

and the appearance of new components. This proved that the effect of combined application was better than that of single application. ③Effect of Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix topical in the treatment of knee osteoarthritis is reliable. Because Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix contain high content of volatile oil that is suitable for transdermal absorption

it is suitable for external use. Notopterygii Rhizoma et Radix and Angelicae Pubescentis Radix play an important role in the clinical application of Huoxue powder

and become important components of Huoxue powder. Huoxue powder is safe

effective and convenient. With the increasing prominence of the problem of drug-induced diseases

the external use of TCM has been paid more and more attention from scholars and experts at home and abroad.