Objective: Through establishing the correlationship of fingerprint-pharmacological effect-drug property to clarify the different effect between Coptidis Rhizoma processed with different ginger juice.Method: Grey relational analysis was applied.The parameters of pharmacological effect and drug property of Coptidis Rhizoma processed with different ginger juice were converted

correlation of common peak area in fingerprint of raw and processed Coptidis Rhizoma were analyzed with the converted parameters.Result: There were 9 common peaks in the fingerprints of Coptidis Rhizoma before and after being processed.The contents of jatrorrhizine hydrochloride

coptisine hydrochloride

berberine hydrochloride and epiberberine in Coptidis Rhizoma processed with fresh ginger juice were all higher than those of Coptidis Rhizoma and Coptidis Rhizoma processed with Zingiberis Rhizoma juice.The peak area of palmatine hydrochloride in Coptidis Rhizoma processed with Zingiberis Rhizoma juice was lower than that of Coptidis Rhizoma and Coptidis Rhizoma processed with fresh ginger juice.The effects in inhibiting Staphylococcus aureus

arresting vomiting and inhibiting gastric mucosal injury of Coptidis Rhizoma processed with fresh ginger juice were better than those of Coptidis Rhizoma processed with Zingiberis Rhizoma juice.The effects in inhibiting Candida albicans

improving the gastrointestinal and decreasing cold property of Coptidis Rhizoma processed with Zingiberis Rhizoma juice were better than those of Coptidis Rhizoma processed with fresh ginger juice.These difference may be related to the content change of jatrorrhizine hydrochloride

coptisine hydrochloride

palmatine hydrochloride

berberine hydrochloride and epiberberine in Coptidis Rhizoma.Conclusion: The results are consistent with the traditional traditional Chinese medicine theory of "the cold nature of Coptidis Rhizoma would be alleviated and its effects of arresting vomiting and promoting gastrointestinal would be enhanced after processed with ginger juice"

different ginger juice will lead to the different change of effective material group

resulting in the pharmacological effect and property difference between Coptidis Rhizoma processed with fresh ginger juice and Zingiberis Rhizoma juice.