Objective: To investigate the material basis and predict the direction of action of Salviae Miltiorrhizae Radix et Rhizoma-Notoginseng Radix et Rhizoma paired drugs. Method: All the molecules

targets and related diseases for Salviae Miltiorrhizae Radix et Rhizoma and Notoginseng Radix et Rhizoma were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Cytoscape 3.2.1 software was used to build the 'active ingredient-target' and 'target-related diseases' network model

and then the material basis and mechanism were studied and predicted. Result: Totally 73 active components

145 targets and 325 related diseases were screened through oral bioavailability (OB) and drug likeness (DL) conditions. The first three active components with higher degree value included quercetin(87)

beta-sitosterol(51) and 1

2

5

6-tetrahydrotanshinone(46). The first three targets with higher degree value included estrogen receptor (63)

androgen receptor (59)

and prostaglandin-endoperoxide synthase 2 (56). The related diseases with higher degree value included cancer (16)

metastatic osteosarcoma in the lung (12)

cardiovascular disease (10)

breast cancer (9) and pancreatic cancer (9)

etc. Conclusion: In this paper

the material basis and mechanism of Salviae Miltiorrhizae Radix et Rhizoma Notoginseng Radix et Rhizoma paired drugs were preliminarily predicted

providing a thinking direction for further research and clinical application.