Objective: To study the relationship between effective ingredients

targets and pathway in Ermiaowan

and predict its possible"Multi-Efficacy of One Formula" Molecular Mechanism based on Network Pharmacology. Method: The main ingredients and targets of Ermiaowan were predicted and screened by relying on A Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine server(BATMAN-TCM). The Search Tool for the Retrieval of Interacting Genes/Proteins platform(STRING) was used to construct target-protein interaction network

and gene ontology(GO) bioprocess enrichment and clustering analysis of target genes were finished by using BiNGO and MCODE plug-ins. Database for Annotation

Visualization and Integrated Discovery(DAVID)was used to analyze kyoto Encyclopedia of Genes and Genomes(KEGG) signaling pathways of the key targets. Result: The active ingredients of Ermiaowan acted on 37 key targets such as serum albumin(ALB)

mitogen-activated protein kinase1(MAPK1)

tumour necrosis factor(TNF)

prostaglandin G/H synthase 2(PTGS2)

5-hydroxytryptamine receptor 2A(HTR2A)

adenosine deaminase(ADA)

glucocorticoid receptor(NR3C1).Got mainly involved in GO biological processes such as inflammation

nerve conduction

metal ions homeostasis

oxidation and reduction

lipid metabolism

and nucleotide metabolism; regulated signaling pathways such as TNF

TRP channel inflammatory

FcεRI

Type Ⅱ diabetes mellitus

calcium signaling pathway

serotonergic and a variety of signal transduction

tumor and cytochrome P450 enzyme. Conclusion: Besides Gout

arthritis

eczema and some inflammatory diseases

Ermiaowan may also have "Multi-Efficacy of One Formula" effect on diabetic peripheral neuropathy

nervous system

gastrointestinal system and cardiovascular system diseases.