基于“肝主宗筋”理论观察柴胡舒肝散加减联用西药治疗前列腺增生的疗效

麻志恒; 倪建俐; 高志生; 黄美琴; 王静

doi:10.13422/j.cnki.syfjx.20181928

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基于“肝主宗筋”理论观察柴胡舒肝散加减联用西药治疗前列腺增生的疗效

临床 | 更新时间：2024-09-23

- 基于“肝主宗筋”理论观察柴胡舒肝散加减联用西药治疗前列腺增生的疗效
- Effect of Modified Chaihu Shugan San Combined with Western Medicine on BPH
- 中国实验方剂学杂志 2018年24卷第21期页码：170-175
- 作者机构：
- 作者简介：
- 基金信息：
  
  上海交通大学医学院附属新华医院崇明分院优青后培养基金计划项目（2016年）
- DOI：10.13422/j.cnki.syfjx.20181928
  中图分类号： R697.3
- 纸质出版日期：2018
- 稿件说明：
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麻志恒, 倪建俐, 高志生, 等. 基于“肝主宗筋”理论观察柴胡舒肝散加减联用西药治疗前列腺增生的疗效[J]. 中国实验方剂学杂志, 2018,24(21):170-175.

MA Zhi-heng, NI Jian-li, GAO Zhi-sheng, et al. Effect of Modified Chaihu Shugan San Combined with Western Medicine on BPH[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(21): 170-175.
麻志恒, 倪建俐, 高志生, 等. 基于“肝主宗筋”理论观察柴胡舒肝散加减联用西药治疗前列腺增生的疗效[J]. 中国实验方剂学杂志, 2018,24(21):170-175. DOI： 10.13422/j.cnki.syfjx.20181928.

MA Zhi-heng, NI Jian-li, GAO Zhi-sheng, et al. Effect of Modified Chaihu Shugan San Combined with Western Medicine on BPH[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(21): 170-175. DOI： 10.13422/j.cnki.syfjx.20181928.

摘要

目的：根据中医"肝主宗筋"理论，提出从肝论治前列腺增生（benign prostatic hyperplasia， BPH），并拟定加减柴胡舒肝散，观察其联合西药治疗BPH气滞血瘀型患者的临床疗效。方法：采用随机数字表法将BPH患者按1：1比例分配至对照组和治疗组，各44例。对照组予盐酸坦索罗辛缓释胶囊加普乐安片治疗，治疗组予盐酸坦索罗辛缓释胶囊加柴胡舒肝散加减治疗，两组治疗各进行3个月。治疗前及治疗后，分别观察两组患者前列腺体积（prostate volume，PV），最大尿流率（maximum flow rate，MFR），残余尿量（postvoid residual volume，PRV），血清前列腺特异性抗原（prostate-specific antigen，PAS），前列腺症状评分（international prostate symptom score，IPSS），生活质量评分（quality of life，QOL），中医证候评分，临床疗效及不良反应的情况。结果：治疗组、对照组临床总有效率分别为87.8%，76.2%，治疗组高于对照组（P<0.05），与本组治疗前比较，两组治疗后PV，PRV，PSA，IPSS评分，中医证候评分均明显下降，MFR，QOL评分均明显上升（P<0.05，P<0.01）；治疗后两组组内比较，治疗组在MFR，PRV，IPSS，QOL及中医证候中的尿频，排尿不畅，夜尿次数，舌脉方面优于对照组（P<0.05，P<0.01）；两组不良反应发生率无统计学差异。结论：柴胡舒肝散加减联和西药治疗，能够改善气滞血瘀型BPH患者的相关指标，临床症状及体征，进而提高临床疗效。

Abstract

Objective: To observe the curative effect of modified Chaihu Shugan San combined with western medicine on benign prostatic hyperplasia (BPH). Method: A total of 88 patients with BPH were divided into two groups. The treatment group (44 cases) was given traditional Chinese medicine(TCM) Chaihu Shugan San combined with western medicine tamsulosin hydrochloride sustained release capsules

and the control group (44 cases) was given western medicine tamsulosin hydrochloride sustained release capsules and Pulean. After 3 months of treatment

the total efficiency

prostate volume (PV)

maximum flow rate(MFR)

bladder residual urine volume (PRV)

serum prostate specific antigen (PSA)

international prostate symptom score (IPSS) and Quality of Life(QOL)

syndrome scores of TCM in two groups were compared. Result: The total effective rates were respectively 87.8% and 76.2% in treatment group and control group

with significant differences (P<0.05). After treatment

the levels of PV

PRV

PSA

IPSS

syndrome scores of TCM were decreased

while MRF

QOL score were increased; some indexes in treatment group were superior to those in control group after treatment(P<0.05

P<0.01). Conclusion: Modified Chaihu Shugan San combined with western medicine has a significant curative effect

and can effectively alleviate the clinical symptoms of patients.

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