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纸质出版日期:2018
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战晓玲, 李沧海, 姜廷良. 表证模型研究概况与展望[J]. 中国实验方剂学杂志, 2018,24(19):213-220.
ZHAN Xiao-ling, LI Cang-hai, JIANG Ting-liang. Overview and Prospect on Superficies Syndrome Model Research[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(19): 213-220.
战晓玲, 李沧海, 姜廷良. 表证模型研究概况与展望[J]. 中国实验方剂学杂志, 2018,24(19):213-220. DOI: 10.13422/j.cnki.syfjx.20181935.
ZHAN Xiao-ling, LI Cang-hai, JIANG Ting-liang. Overview and Prospect on Superficies Syndrome Model Research[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(19): 213-220. DOI: 10.13422/j.cnki.syfjx.20181935.
针对目前中医证候模型研究的整体不足和进展缓慢,立足本课题组对表证方证的几十年研究经验基础上,结合现代科学技术最新进展,综合梳理表证模型相关研究,拟在新型表证模型的建立方面寻找新的切入点。通过检索知网、Pubmed等数据库查阅有关表证模型(或上呼吸道感染)的相关文献,按照造模方法进行了较为详细的阐述、分析和总结,展现进展、不足和可能突破口;近年来表证模型在造模方法、方剂反证、方剂研究、生化表征等方面均取得了长足发展,但也存在与临床联系不紧密、方证对应不理想、成模指标不一致、表证评定标准模糊等诸多不足;提出表证病理模型研究应突破原有的思想羁绊,大胆借鉴现代生命科学进展,努力建立多层次的、更加精细的表证病理模型体系。紧密结合临床加强模型研究,充分吸纳生命科学以及其他学科进展,建立多层次更精细的表证病理模型研究系统是目前亟待解决的核心命题,这关乎表证理论、解表方药及其临床实践的深入研究,也是面对日益严重的疫情下人民健康的迫切需求,同时也可为其他证候模型的研究提供借鉴和参考。
In view of the current overall deficiencies and slow progress in the study of traditional Chinese medicine(TCM) syndrome models
related researches on superficies syndrome model were comprehensively analyzed based on the decades of research experience in superficies syndrome model as well as the latest advances in modern science and technology
so as to find a new breakthrough point in the establishment of the superficies syndrome model. Literature related to superficies syndrome model(or upper respiratory tract infection) was searched on CNKI
Pubmed and other databases
and was elaborated
analyzed and summarized in detail in accordance with the modeling method
showing the progress
shortage and possible breakthrough. Great progress has been made recently in many aspects such as modeling methods
prescription research and test
and biochemical characterization
but there are also many shortcomings such as poor clinical correlation
unsatisfactory correspondence between prescription and syndrome
inconsistent modeling indexes
vague criteria for evaluation of evidences. It is necessary to break through the original thought fetters and draw lessons from the progress on modern life science
and try to establish a multi-level and more elaborate system of pathological model for superficies syndrome. It is the core proposition to strengthen model studies by closely combining with the clinical research
fully absorb the progress of life science and other disciplines
and establish a more sophisticated and more detailed research system for superficies syndrome pathology model
all of which need to be solved urgently. This is helpful for the in-depth study of the superficies syndrome theory
prescription solution and its clinical practice
which can solve the urgent need of people's health in face of the increasingly serious outbreaks
and can also provide reference for researches on other syndrome models.
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