Objective: To discuss the clinical efficacy of addition and subtraction therapy of Qingzao Jiufei Tang to acute exacerbation of chronic bronchitis (wind dryness and lung injury) in plateau area and investigate its influence to inflammatory factors. Method: One hundred and forty patients were randomly divided into control group (70 cases) and observation group (70 cases) by random number table. Both groups received anti-infection treatment

dispelling phlegm and relieving cough. Moxifloxacin hydrochloride tablets for 7 days

0.4 g/time

qd

ambroxol hydrochloride tablets for 14 days

30 mg/time

bid. Patients in control group got Xingsu Zhike granules

12 g/time

bid

taken after being infused in warm boiled water. Patients in observation group got addition and subtraction therapy of Qingzao Jiufei Tang

1 dose/day. The treatment course was 14 days in both groups. Before and after treatment

scores of cough

visual analogue scale (VAS) of cough and scores of wind dryness and lung injury were graded. The disappearance time of cough

phlegm

dry nose and pharynx

rhonchi of lung were recorded. Both before and after treatment

the pulmonary function was detected

and levels of forced vital capacity (FVC)

forced expiratory volume in one second (FEV1)

percentage of FEV1 to expected value (FEV1%)

tumor necrosis factor-α (TNF-α)

interleukin-8 (IL-8)

monocyte chemoattractant protein-1

endothelin (ET) and malondialdehyde (MDA) were detected. Result: The total effective rate for the disease in observation group was 93.65%

better than 81.67%in control group (χ2=4.122

P<0.05). The total clinical effective rate for traditional Chinese medicine(TCM) in observation group was 93.65%

better than 80%in control group (χ2=5.061

P<0.05). Scores of cough symptoms (day and night)

VAS scores of cough and scores of wind dryness and lung injury in observation group were all lower than those in control group (P<0.01). FEV1

FEV1/FVC and FEV1% were improved than those before treatment in both groups (P<0.05)

and the improvement was more obvious in observation group (P<0.05). The disappearance periods of cough

phlegm

dry nose and pharynx

rhonchi of lung in observation group were shorter than those in control group (P<0.05

P<0.01). And the serum levels of MCP-1

IL-8

TNF-α

ET and MDA were lower than those in control group (P<0.01). Conclusion: Based on the routine western medicine treatment for anti-infection

Qingzao Jiufei Tang can quickly control clinical symptoms

shorten course of disease

and ameliorate pulmonary function

with anti-inflammatory and anti-oxidative stress functions when it is used for chronic bronchitis (wind dryness and lung injury) at acute exacerbation in plateau area.