Objective: To explore the relationship of "component-target-disease" of Shenling Baizhusan on treatment of type 2 diabetes with integrated pharmacological method. Method: Active ingredients and potential targets of all herbs in Shenling Baizhusan were searched by integrated pharmacological method

disease targets of type 2 diabetes were searched

and their enrichment analysis was carried out. Result: There were 499 chemical compositions in Shenling Baizhusan

and there could be a strong synergistic interaction between herbs

according to the results of gene ontology database and enrichment of Kyoto encyclopedia of genes and genomes

chemical compositions of corresponding key target was located in the cytoplasm

mitochondria

myelin sheath

etc;and involved 1 481 biological processes and gene function

such as regulation of adenosine triphosphate binding

protein kinase activity

etc;and participated in 179 related pathways

such as purine metabolism

nucleotide metabolism and nervous system

to treat type 2 diabetes. Conclusion: This study screens out the chemical constituents in Shenling Baizhusan by integrated pharmacological platform of traditional Chinese medicine

and predicts its targets and related pathways for treatment of type 2 diabetes

which may be closely related to glucose and lipid metabolism

energy metabolism

etc.