补骨脂化学成分及药理作用研究进展

鲁亚奇; 张晓; 王金金; 李凯; 周宁; 张振凌

doi:10.13422/j.cnki.syfjx.20182022

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补骨脂化学成分及药理作用研究进展

综述 | 更新时间：2021-02-09

- 补骨脂化学成分及药理作用研究进展
- Research Progress on Chemical Constituents and Pharmacological Actions of Psoralea Fructus
- 中国实验方剂学杂志 2019年25卷第3期页码：180-189
- 作者机构：
  
  1.河南中医药大学，郑州　 450046
  2.呼吸疾病诊疗与新药研发河南省协同创新中心，郑州　 450046
- 作者简介：
  
  鲁亚奇，在读硕士，从事中药活性成分研究，Tel: 0371-65676656，E-mail:luyaqi412@163.com
  *李凯，博士，副教授，从事中药炮制研究，Tel: 0371-65676656，E-mail: cpulikai@163.com
- 基金信息：
  
  河南省高等学校重点科研项目(19A360001);国家自然科学基金项目(81403102)
- DOI：10.13422/j.cnki.syfjx.20182022
  中图分类号： R284.1;R289;R22;R2-031
- 收稿日期：2018-04-06，
  
  网络出版日期：2018-07-27，
  
  纸质出版日期：2019-02-05
- 稿件说明：
移动端阅览
鲁亚奇, 张晓, 王金金, 等. 补骨脂化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(3):180-189.

Ya-qi LU, Xiao ZHANG, Jin-jin WANG, et al. Research Progress on Chemical Constituents and Pharmacological Actions of Psoralea Fructus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 180-189.
鲁亚奇, 张晓, 王金金, 等. 补骨脂化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019,25(3):180-189. DOI： 10.13422/j.cnki.syfjx.20182022.

Ya-qi LU, Xiao ZHANG, Jin-jin WANG, et al. Research Progress on Chemical Constituents and Pharmacological Actions of Psoralea Fructus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 180-189. DOI： 10.13422/j.cnki.syfjx.20182022.

摘要

补骨脂是临床常用中药，其性温，味辛、苦，归肾、脾经，具有温肾助阳、纳气平喘、温脾止泻的作用，外用消风祛斑。近些年来，补骨脂的化学及药理作用研究取得长足进展，学者已从中分离出近百种香豆素类、黄酮类、单萜酚类化合物，也发现其中含类脂类、糖苷类、挥发油以及微量元素等多种类型的化合物。该文通过查阅原始文献，总结了主要化合物类型及化学分子式，详细综述了其在抗肿瘤、抗氧化、抗菌、抗炎、抗抑郁、调节雌激素水平、促进骨生长、神经保护及对肝脏的影响等方面的药理作用，并将具有相同或相似药理作用的化合物分类总结，以寻找补骨脂中化学成分与其药理作用之间的关系。补骨脂及以其开发的现代制剂在现代临床中应用较为广泛，该文通过查阅国内外补骨脂中化学成分研究文献及其近些年的药理活性研究文献，系统整理、分析、总结了其化学成分和药理活性的研究进展，更正了个别化合物的化学类型，以期为补骨脂药效物质基础、质量标准及药理活性的深入研究提供参考。

Abstract

Psoralea Fructus

a commonly used traditional Chinese medicine in clinical application

is warm

spicy and bitter in nature and belongs to the kidney and spleen meridian. Psoralea Fructus has the function of warming kidney and tonifying yang

absorbing Qi and relieving asthma

warming spleen and stopping diarrhea

and in topical use

it can remove beverage. In recent years

considerable progress has been made in the study of chemical constituents and pharmacological effects of Psoralea Fructus. Nearly one hundred compounds have been isolated from it

including coumarins

flavonoids

and meroterpenes

and various types of compounds such as lipids

glycosides

volatile oils

and trace elements have been also found in Psoralea Fructus. In this article

the original literature was reviewed to summarize the main compound types and structural formula

with detailed reviews on pharmacological studies about its anti-tumor

anti-oxidant

anti-bacterial

anti-inflammatory

anti-depressive

regulating estrogen level

promoting bone growth

liver protection

and neuroprotection effects. In addition

the compounds with the same or similar pharmacological effects were sorted out and summarized to correlate the chemical structure and pharmacology. Psoralea Fructus and its modern preparations are widely used in modern clinical practice. The researches and papers on chemical constituents of Psoralea Fructus at home and abroad and the papers on pharmacological activities in recent years were reviewed

and the chemical types of individual compounds were corrected in this article

providing a reference for further study of Psoralea Fructus in efficacy material basis

quality standards and pharmacological activities.

关键词

Keywords

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