卒中得生丸联合原络通经针法治疗卒中后认知障碍的临床分析

张淼; 武文鹏; 夏昆鹏; 祝鹏宇

doi:10.13422/j.cnki.syfjx.20182043

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卒中得生丸联合原络通经针法治疗卒中后认知障碍的临床分析

临床 | 更新时间：2024-01-04

- 卒中得生丸联合原络通经针法治疗卒中后认知障碍的临床分析
- Clinical Analysis of Cuzhong Desheng Pills Combined with Acupuncture and Moxibustion Therapy of Yuanluo Tongjing on Post-stroke Cognitive Impairment
- 中国实验方剂学杂志 2018年24卷第20期页码：186-191
- 作者机构：
- 作者简介：
- 基金信息：
  
  黑龙江省自然科学基金项目（H201319）;哈尔滨市科技计划-技术应用与研究开发项目（2016RAYYJ06）
- DOI：10.13422/j.cnki.syfjx.20182043
  中图分类号： R277.7
- 纸质出版日期：2018
- 稿件说明：
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张淼, 武文鹏, 夏昆鹏, 等. 卒中得生丸联合原络通经针法治疗卒中后认知障碍的临床分析[J]. 中国实验方剂学杂志, 2018,24(20):186-191.

ZHANG Miao, WU Wen-peng, XIA Kun-peng, et al. Clinical Analysis of Cuzhong Desheng Pills Combined with Acupuncture and Moxibustion Therapy of Yuanluo Tongjing on Post-stroke Cognitive Impairment[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(20): 186-191.
张淼, 武文鹏, 夏昆鹏, 等. 卒中得生丸联合原络通经针法治疗卒中后认知障碍的临床分析[J]. 中国实验方剂学杂志, 2018,24(20):186-191. DOI： 10.13422/j.cnki.syfjx.20182043.

ZHANG Miao, WU Wen-peng, XIA Kun-peng, et al. Clinical Analysis of Cuzhong Desheng Pills Combined with Acupuncture and Moxibustion Therapy of Yuanluo Tongjing on Post-stroke Cognitive Impairment[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(20): 186-191. DOI： 10.13422/j.cnki.syfjx.20182043.

摘要

目的：探讨卒中得生丸联合原络通经针法治疗卒中后认知障碍（PSCI）瘀阻脑络证的临床疗效及抗炎和抗氧化作用。方法：将114例患者以诊疗先后，按随机数字表法分为对照组和观察组各57例。两组患者均口服多奈哌齐片，10 mg/次，1次/d。对照组采用原络通经针法，1次/d，6次/周。观察组在对照组治疗的基础上给予卒中得生丸，10 g/次，3次/d，口服。两组疗程均为连续治疗4周。采用简易智力状态检查量表（MMSE）和蒙特利尔认知评估量表（MoCA）评价认知功能，进行治疗前后日常生活能力（ADL），神经功能缺损（NIHSS）和瘀阻脑络证评分；进行治疗前后听觉P300电位检测；检测治疗前后白细胞介素-1β（IL-1β），IL-6，肿瘤坏死因子-α（TNF-α），超氧化物歧化酶（SOD）和丙二醛（MDA）水平。结果：经Ridit分析，观察组MMSE疗效和中医证候疗效均优于对照组（P<0.05）；观察组患者MoCA和MMSE评分均高于对照组（P<0.01）；观察组患者ADL高于对照组，NIHSS和瘀阻脑络证评分均低于对照组（P<0.01）；观察组患者N2和P3潜伏期均短于对照组，波幅高于对照组（P<0.01）；观察组患者血清IL-1β，IL-6，TNF-α和MDA水平均低于对照组，SOD水平高于对照组（P<0.01）。结论：卒中得生丸联合原络通经针法能进一步改善PSCI瘀阻脑络证患者认识功能，减轻临床症状，提高生活自理能力，并具有抗炎和抗氧化损伤的作用。

Abstract

Objective: To observe the clinical efficacy of Cuzhong Desheng pills combined with acupuncture and moxibustion therapy of Yuanluo Tongjing to post-stroke cognitive impairment (PSCI) with syndrome of blood stasis blocking brain and investigate its antioxidation.Method: One hundred and fourteen patients were randomly divided into control group (57 cases) and observation group (57 cases) by random number table. Both groups received donepezil tablet

10 mg/time

qd. Patients in control group got acupuncture and moxibustion therapy of yuanluo tongjing

6 times/week. Based on the treatment in control group

patients in observation group additionally received Cuzhong Desheng pills

10 g/time

tid. The treatment course was 4 weeks in both groups. Cognitive function was discussed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA). And before and after treatment

scores of activity of daily living scale (ADL)

national institute of health stroke scale (NIHSS) and syndrome of blood stasis blocking brain were graded. Hearing potential of P300 and levels of interleukins-1β (IL-1β)

interleukins-6 (IL-6)

tumor necrosis factor-α (TNF-α)

superoxide dismutase (SOD) and malondialdehyde (MDA) were detected before and after treatment.Result: Ridit analysis showed that the efficacy of MMSE and traditional Chinese medicine (TCM) syndrome efficacy in observation group were better than those in control group (P<0.05). Scores of MoCA and MMSE in observation group were higher than those in control group (P<0.01). Score of ADL and level of SOD in observation group were higher than those in control group (P<0.01). Scores of NIHSS and syndrome of blood stasis blocking brain

and levels of IL-1β

IL-6

TNF-α and MDA were lower than those in control group (P<0.01). Incubation periods of N2 and P3 were shorter than those in control group

but amplitude was higher than that in control group (P<0.01).Conclusion: Treatment of Cuzhong Desheng pills combined with acupuncture and moxibustion therapy of Yuanluo Tongjing can ameliorate cognitive function of patients with PSCI and syndrome of blood stasis blocking brain

and can relieve clinical symptoms

improve self-care ability

with anti-inflammatory and anti-oxidative damage effects.

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