Objective:To explore the clinical effect of Jichuanjian in treatment of elderly with chronic functional constipation (CFC). Method:The 118 elderly with CFC in our hospital from February 2016 to February 2018 were selected as research objectives

and divided into two groups according to random number table. The patients in control group (59 cases) received prucalopride succinate tablets

and prucalopride succinate tablets combined with Jichanjian was given to the patients in observation group (59 cases). All patients were treated for 1 month. The clinical efficacy

gastrointestinal function indicators

intestinal neurotransmitters[nitrogen monoxide (NO)

serotonin (5-HT)

substance P (SP)] and intestinal flora before and after treatment

as well as adverse reaction were compared between two groups. Result:After 1 month treatment

the overall effective rate was 93.2%(55/59) in observation group

significant higher than that in control group[78.0%(46/59)

P<0.05]. The whole gastrointestinal tract discharge rate and gastric emptying rate after treatment were significant higher than those before treatment in both groups (P<0.05)

and the increase in observation group was more obvious than that in control group(P<0.05). As compared with those before treatment

the serum NO levels were significant lower (P<0.05)

while serum SP

5-HT concentrations were significant higher after treatment in both groups (P<0.05)

and improvement in observation group was more obvious than that in control group(P<0.05). The number of gastrointestinal anaerobes lactobacillus and bifidobacteria was significant higher than that before treatment after treatment in both groups (P<0.05)

while the number of aerobic bacteria yeast and enterobacteria was significant lower than that before treatment (P<0.05)

and the improvement in observation group was more obvious than that in control group(P<0.05). As compared with the conditions before treatment

the scores for symptoms of defecation (fecal characteristics

defecation interval

difficulty in defecation

and incomplete defecation) were significantly reduced in both groups after treatment (P<0.05). As compared with control group

defecation symptom scores of the patients in observation group were decreased more significantly (P<0.05). In addition

there was no significant difference in adverse reaction rate between observation group[6.8% (4/59)] and control group[3.4% (2/59)]. Conclusion:The use of Jichuanjian adjuvant therapy can significantly relieve the symptoms in elder patients with CFC

enhance gastrointestinal function

regulate the expression level of intestinal neurotransmitters

and maintain intestinal microbiota homeostasis

with significant clinical effect and high safety.