Objective:To explore and analysis the value and significance of the combined application of Danshen injection on vasodilatation and inflammation in patients with diabetes mellitus combined with lower extremity vascular disease. Method:A total of 136 patients with diabetes mellitus combined with lower extremity vascular disease treated in our hospital from January 2015 to December 2016 were selected as clinical research subjects. By the random number table method

the patients were randomly divided into observation group (69 cases) and control group (67 cases). The patients with diabetes mellitus combined with lower extremity vascular disease in control group were treated with α-lipoic acid. The patients with diabetes mellitus combined with lower extremity vascular disease in observation group were treated with Danshen injection in addition to the therapy of control group. The clinical treatment

changes in vasodilation

hemodynamic changes

changes in inflammatory markers

adverse reactions of the patients with diabetes mellitus combined with lower extremity vascular disease in the two groups were compared and analyzed. Result:Compared with control group

the effective rate of clinical treatment in observation group was 50.72% (35/69)

and the total effective rate was 95.65% (66/69)

indicating a significant increase

while the inefficiency rate was 4.35% (3/69)

indicating a significant decrease. There were statistically significant differences (P<0.05). In observation group

flow-mediated dilatation (FMD) was (5.31±0.64)% and ankle brachial index (ABI) was (0.99±0.12)

with statistically significant differences (P<0.05); the intravascular diameter was (1.70±0.28) mm

the blood flow velocity was (52.29±6.34)min·s-1

and the blood flow volume was (24.39±3.54) mL·min-1

with statistically significant differences (P<0.05); C-reactive protein (CRP) was (5.46±0.65) mg·L-1

interleukin (IL)-6 was (81.84±9.29) μg·L-1 and tumor necrosis factor (TNF) -α was (11.53±2.26) μg·L-1

with statistically significant differences (P<0.05); total incidence of adverse reactions was 8.70% (6/69)

including nausea and vomiting

headbilges and headache

abdominal pain and diarrhea

with statistically significant differences. Conclusion:In the process of the adjuvant treatment for the patients with diabetes mellitus combined with lower extremity vascular disease with Danshen injection

Danshen injection could effectively alleviate the patients' vasodilatation and hemodynamic indicators

and regulate the patient's inflammatory cytokines in an all-round way

so as to enhance the patients' clinical treatment.