正交试验优选盐泽泻的炮制生产工艺

邰艳妮; 樊李明; 陈秀霞; 褚克丹; 林青青; 金琦; 冯琳雪; 谢瑞华

doi:10.13422/j.cnki.syfjx.20182205

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正交试验优选盐泽泻的炮制生产工艺

药剂与炮制 | 更新时间：2024-09-23

- 正交试验优选盐泽泻的炮制生产工艺
- Optimization of Production Process of Alismatis Rhizoma Processed with Salt by Orthogonal Test
- 中国实验方剂学杂志 2018年24卷第23期页码：37-45
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中药标准化项目（ZYBZH-Y-FJ-09）;福建省中药原料质量监测技术服务中心（财社[2014]76号）
- DOI：10.13422/j.cnki.syfjx.20182205
  中图分类号： R283
- 纸质出版日期：2018
- 稿件说明：
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邰艳妮, 樊李明, 陈秀霞, 等. 正交试验优选盐泽泻的炮制生产工艺[J]. 中国实验方剂学杂志, 2018,24(23):37-45.

TAI Yan-ni, FAN Li-ming, CHEN Xiu-xia, et al. Optimization of Production Process of Alismatis Rhizoma Processed with Salt by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(23): 37-45.
邰艳妮, 樊李明, 陈秀霞, 等. 正交试验优选盐泽泻的炮制生产工艺[J]. 中国实验方剂学杂志, 2018,24(23):37-45. DOI： 10.13422/j.cnki.syfjx.20182205.

TAI Yan-ni, FAN Li-ming, CHEN Xiu-xia, et al. Optimization of Production Process of Alismatis Rhizoma Processed with Salt by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(23): 37-45. DOI： 10.13422/j.cnki.syfjx.20182205.

摘要

目的：优化盐泽泻的炮制工艺，明确其工艺参数，为盐泽泻的规范化生产和质量控制提供实验依据。方法：以环氧泽泻烯，23-乙酰泽泻醇C，泽泻烯醇，泽泻醇B和23-乙酰泽泻醇B成分总量、醇溶性浸出物质量分数和外观性状评分的综合评分为指标，采用单因素试验和正交试验考察闷润温度、闷润时间、切片厚度和干燥温度及盐炙工艺中的盐浓度、盐水闷润时间、溶液用量、炒制温度和炒制时间对盐泽泻炮制工艺的影响。采用UPLC测定5个指标成分的含量，流动相乙腈-水梯度洗脱，检测波长208 nm。结果：盐泽泻最佳炮制工艺为泽泻药材75℃闷润1.0 h后趁热切4 mm厚片，65℃干燥得到泽泻饮片，每100 kg泽泻饮片加盐水13 kg（溶解了2.0 kg盐），闷润3 h，在160℃下炒制8 min。结论：优化的盐泽泻中试生产工艺具有较好的可行性和可控性，适用于盐泽泻的工业化生产。

Abstract

Objective:To optimize the processing technology of Alismatis Rhizoma with salt

and clarify the processing parameters

in order to provide the basis for standardized production and quality control of Alismatis Rhizoma. Method:With comprehensive score of total content of five ingredients(alismoxide

23-acetyl alisol C

alisenol

alisol B and 23-acetyl alisol B)

content of alcohol soluble extract and appearance score as indicator

single factor tests and orthogonal test were adopted to optimize processing technology of salt-processed Alismatis Rhizoma by taking moistening temperature

moistening time

slice thickness and others as factors.UPLC was employed to determine contents of these five ingredients with mobile phase of acetonitrile-water for gradient elution and detection wavelength at 208 nm. Result:Optimum processing technology of salt-processed Alismatis Rhizoma was as followings:moistening temperature of 75℃

slice thicknesses of 4 mm

moistening time of 1.0 h

drying temperature of 65℃

2 kg salt dissolved with 13 kg water for each 100 kg of Alismatis Rhizoma

moistening for 3 h

stir-frying for 8 minutes under 160℃. Conclusion:This optimized production process of salt-processed Alismatis Rhizoma has good feasibility and controllability

which is suitable for industrial production of this decoction pieces.

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