中药治疗乳腺癌疾病研究进展

李云祥; 梁引库; 高飞雄; 段红波; 宦臣臣

doi:10.13422/j.cnki.syfjx.20182328

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中药治疗乳腺癌疾病研究进展

综述 | 更新时间：2021-02-09

- 中药治疗乳腺癌疾病研究进展
- Research Progress of Traditional Chinese Medicine in Treating Breast Cancer
- 中国实验方剂学杂志 2019年25卷第3期页码：211-219
- 作者机构：
  
  陕西理工大学　陕西省资源生物重点实验室，生物科学与工程学院，陕西　汉中　 723000
- 作者简介：
  
  李云祥，在读硕士，从事应用生物化学研究，E-mail: liyunxiang19930125@163.com
  *梁引库，博士，副教授，硕士生导师，从事天然产物活性物质开发利用研究，E-mail: liangyinku26@163.com
- 基金信息：
  
  陕西省资源生物重点实验室项目(SZS-15-03);秦巴山区生物资源综合开发协同创新中心项目(QBXT-Z (Y) -15-2);陕西理工大学研究生创新基金项目(SLGYCX1835)
- DOI：10.13422/j.cnki.syfjx.20182328
  中图分类号： R22;R242;R2-031;R287;R273
- 收稿日期：2018-05-22，
  
  网络出版日期：2018-09-12，
  
  纸质出版日期：2019-02-05
- 稿件说明：
移动端阅览
李云祥, 梁引库, 高飞雄, 等. 中药治疗乳腺癌疾病研究进展[J]. 中国实验方剂学杂志, 2019,25(3):211-219.

Yun-xiang LI, Yin-ku LIANG, Fei-xiong GAO, et al. Research Progress of Traditional Chinese Medicine in Treating Breast Cancer[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 211-219.
李云祥, 梁引库, 高飞雄, 等. 中药治疗乳腺癌疾病研究进展[J]. 中国实验方剂学杂志, 2019,25(3):211-219. DOI： 10.13422/j.cnki.syfjx.20182328.

Yun-xiang LI, Yin-ku LIANG, Fei-xiong GAO, et al. Research Progress of Traditional Chinese Medicine in Treating Breast Cancer[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(3): 211-219. DOI： 10.13422/j.cnki.syfjx.20182328.

摘要

乳腺癌是女性人群中较为多见疾病之一。它是一种具有多种复杂机制的恶性肿瘤，其发病机制尚未研究清楚，物理、化学和手术治疗手段对女性治疗往往带来呕吐、恶心、头晕、头痛等不良表现。与传统治疗相比，中药治疗乳腺癌具有多靶点、毒副作用小、效果好等特点。本文首先统计了能够治疗乳腺癌的中药有85种，其中69种中药材已被2015年版《中国药典》收录，16种中草药未被收录。这些中草药中治疗乳腺癌的主要药用成分为生物碱、苷类、酚类、萜类、糖类、挥发油、香豆素等，并且按照中药对乳腺癌的作用进行了归类。然后，本文结合国内外最近研究，对中药治疗乳腺癌作用效果进行了归纳总结，包括中药对乳腺癌逆转多药耐药作用、抑制乳腺癌转移作用、增殖作用、诱导肿瘤细胞凋亡作用以及阻滞乳腺癌细胞周期作用。文章也从中药干预治疗乳腺癌3个方面途径机制进行了阐述，分别为中药干预肿瘤细胞相关凋亡基因抑制乳腺癌，抑制细胞膜P糖蛋白的表达逆转乳腺癌细胞多药耐药性，调节相关上皮间质转化信号通路阻止乳腺癌细胞的转移和增殖。中药可降低乳腺癌的耐药性和乳腺癌细胞的转移，可阻滞乳腺癌细胞周期作用，也导致凋亡因子的表达从而促使乳腺癌细胞死亡，中药抑制乳腺癌是中药中多种成分共同作用的结果。因此中药治疗乳腺癌具有化学药、手术治疗无可比拟的优势。中药是治疗乳腺癌疾病的重要手段之一。

Abstract

Breast cancer is one of the common diseases among women. It is a malignant tumor with a variety of complex mechanisms. Its pathogenesis has not been clearly studied. Physical

chemical and surgical treatments often cause vomiting

nausea

dizziness and headache for women. As compared with traditional treatment

Chinese medicine is characterized by multiple targets

small side effect and good effect in treating breast cancer. In this paper

85 kinds of Chinese herbal medicines that can treat breast cancer were included. Among them

69 kinds of Chinese herbal medicines have been included in the 2015 edition of the

Chinese Pharmacopoeia

and 16 kinds of Chinese herbal medicines have not been included. The main medicinal ingredients in these Chinese herbal medicines for treatment of breast cancer were alkaloids

glycosides

phenols

terpenes

carbohydrates

volatile oils

coumarins and so on. In addition

these herbal medicines were classified according to their effects in breast cancer. Then

combined with the recent studies at home and abroad

this paper summarized the effect of traditional Chinese medicine(TCM) on breast cancer

including the reversal of multi-drug resistance

the inhibition of metastasis and proliferation

the induction of tumor cell apoptosis

and the arrest of the cell cycle for breast cancer. This paper also explained three pathways for treating breast cancer by TCM

including intervening the tumor cell related apoptosis gene to inhibit breast cancer

inhibiting the expression of P-glycoprotein in the cell membrane to reverse the multi-drug resistance of breast cancer cells

and regulating the related epithelial mesenchymal transition signal pathway to prevent breast cancer cells metastasis and proliferation. In the end

it was concluded that Chinese medicine can reduce the drug resistance and metastasis of breast cancer cells

block the cell cycle of breast cancer cells

and also intervene the expression of apoptotic factors to promote the death of breast cancer cells. The inhibition of breast cancer by Chinese medicine was the result of the common effect of various ingredients. Therefore

Chinese medicine treatment for breast cancer has the unparalleled advantages as compared with chemical and surgical treatment. Chinese medicine is one of our important means to overcome breast cancer.

关键词

Keywords

references

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