The emergence of antibiotics has made great contribution to the treatment of infectious diseases and the improvement of human health. However

with the intensive use of antibiotics

especially their abuse

bacterial resistance becomes increasingly serious. The increase and spread of drug-resistant bacteria seriously threaten human health. Bacterial resistance has been a global health problem. On one side

more and more bacteria become resistant to the commonly used antibiotics

and there have been even "super bacteria"; on the other side

it takes a long time to develop new chemically synthetic drugs with antibacterial activity. Chinese herbal medicine has a history of several thousand years in China

with many advantages

such as abundant resources

less adverse effects and rare drug resistance. Therefore

developing new antibacterial Chinese herbal medicine

especially those against bacterial resistance

has increasingly become a research hotspot. The authors made a review of the research progress on antimicrobial resistance of Chinese herbal medicine

including the recent reports of antibacterial activity of Chinese herbal medicine and their mechanisms

the factors affecting antibacterial activity and the prospect in this field

in the hope of providing a reference for further study of exploring traditional Chinese herbal medicines as sources of antimicrobial resistance drugs.