加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物，Th1/Th2型细胞因子表达水平的影响

文丽芳; 丁洁

doi:10.13422/j.cnki.syfjx.20182426

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加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物，Th1/Th2型细胞因子表达水平的影响

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- 加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物，Th1/Th2型细胞因子表达水平的影响
- Effect of Modified Renseng Yangrong Tang Combined with Chemotherapy on Serum Tumor Markers and Th1/Th2-type Cytokines Expression in Cervical Cancer Patients
- 中国实验方剂学杂志 2019年25卷第5期页码：68-72
- 作者机构：
  
  1.山西医科大学　汾阳学院，山西　汾阳　 032200；
  2.山西医科大学　附属汾阳医院，山西　汾阳　 032200
- 作者简介：
  
  文丽芳，硕士，讲师，从事妇科肿瘤研究，Tel：0358-2100667，E-mail: loneynny@126.com
- 基金信息：
  
  山西医科大学汾阳学院校内科研项目(2018D01)
- DOI：10.13422/j.cnki.syfjx.20182426
  中图分类号： R22;R242;R2-031;R287
- 收稿日期：2018-07-09，
  
  纸质出版日期：2019-03-05
- 稿件说明：
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文丽芳, 丁洁. 加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物，Th1/Th2型细胞因子表达水平的影响[J]. 中国实验方剂学杂志, 2019,25(5):68-72.

Li-fang WEN, Jie DING. Effect of Modified Renseng Yangrong Tang Combined with Chemotherapy on Serum Tumor Markers and Th1/Th2-type Cytokines Expression in Cervical Cancer Patients[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 68-72.
文丽芳, 丁洁. 加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物，Th1/Th2型细胞因子表达水平的影响[J]. 中国实验方剂学杂志, 2019,25(5):68-72. DOI： 10.13422/j.cnki.syfjx.20182426.

Li-fang WEN, Jie DING. Effect of Modified Renseng Yangrong Tang Combined with Chemotherapy on Serum Tumor Markers and Th1/Th2-type Cytokines Expression in Cervical Cancer Patients[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(5): 68-72. DOI： 10.13422/j.cnki.syfjx.20182426.

摘要

目的：

探究宫颈癌患者行加味人参养荣汤联合化疗治疗的效果及对血清肿瘤标志物，Th1/Th2型细胞因子水平的影响。

方法：

选取2014年12月至2017年12月山西医科大学附属汾阳医院收治的宫颈癌患者114例为研究对象。依据随机数表法分为两组，对照组(57例)行常规单纯化疗，研究组(57例)在常规化疗基础上给予加味人参养荣汤治疗。观察两组中医症状积分、血清肿瘤标志物[癌胚抗原(carcinoembryonic antigen

CEA)，鳞状上皮细胞癌抗原(squamous cell carcinoma antigen

SCCA)，糖类抗原125(saccharide antigen 125

CA125)]及Th1/Th2型细胞因子[

-干扰素(interferon-

IFN-

)，白细胞介素(interleukin

IL)-4，IL-2，IL-6]水平、治疗3个月后临床疗效、不良反应率。

结果：

治疗前两组中医症状积分、血清肿瘤标志物及Th1/Th2型细胞因子水平无统计学差异；治疗后研究组中医症状积分，CEA

SCCA

CA125，IL-6，IL-4水平均低于对照组及本组治疗前(

0.05)，IL-2，IFN-

水平高于对照组及本组治疗前(

0.05)。治疗组患者治疗后在躯体功能、整体健康、机体疼痛、社会功能、活力及心理卫生方面均优于对照组(

0.05)，而在躯体角色、情绪角色方面两者无明显差异。研究组近期治疗总有效率(82.46%)高于对照组(64.91%)；不良反应率(14.04%)低于对照组(29.82%)(

＝4.524，4.150，

0.05)。

结论：

加味人参养荣汤应用于宫颈癌化疗患者可显著缓解临床症状，降低血清肿瘤标志物水平，改善细胞免疫水平，提高近期治疗效果，并可减少不良反应。

Abstract

Objective:

To investigate the effect of modified Renseng Yangrong Tang combined with chemotherapy on serum tumor markers and Th1/Th2 type cytokines expression in cervical cancer patients.

Method:

A total of 114 patients with cervical cancer admitted in our hospital from December 2014 to December 2017 were selected as the study subjects. According to the random number table method

the patients were divided into two groups. The control group (57 cases) was treated with conventional chemotherapy. The treatment group (57 cases) was treated with modified Renseng Yangrong Tang in addition to the conventional chemotherapy. Traditional Chinese medicine (TCM) symptom scores

serum tumor markers [carcinoembryonic antigen (CEA)

squamous cell carcinoma antigen (SCCA)

carbohydrate antigen 125 (CA125)]and Th1/Th2 type cytokine [interferon gamma-interferon (IFN-

)

interleukin-4 (IL-4)

interleukin-2 (IL-2)

interleukin-6 (IL-6) levels]

clinical efficacy after treatment 3 months

and adverse reaction rate of two groups were observed.

Result:

There was no significant difference in TCM symptom scores

serum tumor markers and Th1/Th2 cytokines between the two groups before treatment. After treatment

the TCM symptom scores

CEA

SCCA

CA125

IL-6

and IL-4 levels in the treatment group were lower than those in control group and before treatment (

0.05). The levels of IL-2 and IFN-

were higher than those in the control group and before treatment (

0.05). The patients in treatment group were significantly better than those in control group in terms of physical function

mental health

overall health

body pain

social function and vitality (

0.05)

but there was no significant difference in physical role and emotional role. The total effective rate of treatment group (82.46%) was higher than that of control group (64.91%)

and the adverse reaction rate (14.04%) was lower than control group (29.82%). The difference was statistically significant (

=4.524

4.150

0.05).

Conclusion:

Modified Renseng Yangrong Tang can significantly relieve clinical symptoms

reduce the level of serum tumor markers

improve cellular immunity

improve the recent therapeutic effect

and reduce adverse reactions in patients with cervical cancer chemotherapy.

关键词

Keywords

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