PAN Xiang-long, HAO Er-wei, XIE Jin-ling, et al. Molecular Mechanism of Blood-activating and Stasis-removing Chinese Medicine in Regulating Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(24): 227-234.
PAN Xiang-long, HAO Er-wei, XIE Jin-ling, et al. Molecular Mechanism of Blood-activating and Stasis-removing Chinese Medicine in Regulating Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(24): 227-234. DOI: 10.13422/j.cnki.syfjx.20182434.
With the functions of promoting blood circulation and dispelling blood stasis
Blood-activating and Stasis-removing Chinese Medicine has been widely used for treatment of blood stasis syndrome in clinical application.Traditional Chinese medicine can fully modulate the body's prevention function for diseases
and play a multi-angle
multi-level
and multi-target comprehensive regulatory ability to achieve therapeutic effect by acting on different tissues and organs. At present
there are many related studies on blood stasis syndrome
but they mainly focus on efficacy observation and prescription summary
lacking in-depth study and summary of the mechanism of action of traditional Chinese medicine(TCM). TCM treatment for diseases attaches importance on the overall concept
but because of its complex chemical compositions
diverse forms of the formula
complex mechanism of action
and numerous interference factors
the interaction between multiple links and multiple targets of drugs and diseases is not understood thoroughly. In recent years
TCM has accumulated rich clinical practice experience in the application of blood-activating and stasis-removing Chinese Medicine
and has elucidated the molecular mechanism of blood stasis syndrome from overall concept
organs
cells
and molecules. In order to clarify the ways and targets of blood-activating and stasis-removing Chinese medicine
this article reviewed the relevant molecular mechanisms of blood-activating and stasis-removing Chinese medicine for treatment of blood stasis syndrome by systematically reviewing and summarizing the relevant molecular data at home and abroad. Its molecular mechanism was investigated from hemodynamics
hemorheology
anti-thrombosis
microcirculatory disorders
vascular endothelial injury
anti-inflammatory response and other aspects
providing reference and basis for Chinese medicine treatment for blood stasis syndrome as well as its further development and utilization.