Objective:

2

To study on the pharmacokinetics and tissue distribution of baicalin magnesium salt in rats after tail vein injection

and compare pharmacokinetic differences between baicalin magnesium salt and baicalin.

Method:

2

After tail vein injection of baicalin magnesium salt and baicalin

orbital blood was collected at different time points.The drug concentration was measured by HPLC

the drug concentration-time curve was plotted

the pharmacokinetic parameters were calculated with DAS 3.0 software

SPSS 19.0 software was used for statistical analysis.At the same time

the drug distribution in heart

liver

spleen

lung and kidney was measured at different time points after tail vein injection of baicalin magnesium salt.

Result:

2

When the dose of baicalin magnesium salt was 25-100 mg·kg

-1

area under the curve(AUC

0-

t

and AUC

0-∞

) showed a good linear relationship with the dose(

r

>

0.95)

but most of the other pharmacokinetic parameters had no significant difference between different dose groups.The mean residence time(MRT

0-

t

) of medium dose group of baicalin magnesium salt was significantly higher than that of equal molar dose group of baicalin.After intravenous injection of baicalin magnesium salt

the drug concentration was the highest in each tissue at 0.25 h

and the concentration of target component decreased rapidly at 0.75 h. The distribution of target component in kidney was the most

followed by lung.

Conclusion:

2

After injection

the baicalin magnesium salt can be rapidly distributed and quickly eliminated

in vivo

which is mainly excreted from the kidney.