Objective:

2

To observe the clinical effect of Jiawei Xijiao Dihuang Tang on Henoch-schonlein purpura nephritis of children with blood heat and stasis syndrome and the inflammatory factors and coagulation function.

Method:

2

One hundred and twenty-two patients were divided into control group (60 cases) and observation group (62 cases) by random number table. Patients in control group got prednisolone acetate tablets every day

1.5-2 mg·kg

-1

·d

-1

after 4 weeks

of the treatment

and the 4 weeks dosage decreased progressively. Patients in control group also got dipyridamole tablets

3-5 mg·kg

-1

·d

-1

and compound rutin tablets

1 tablet/day

3 times/days. In addition to the therapy of control group

patients in observation group were also given Jiawei Xijiao Dihuang Tang

1 dose/day. And one course of treatment was 12 weeks. Before and after treatment

blood heat and stasis syndrome were graded. And levels of urinary

β

2

microglobulin (

β

2

-MG)

24-hour urine protein quantitative (24 h UmAlb)

microalbuminuria (mAlb)

cystatin C (CysC)

platelet count (PLT)

plasma prothrombin time (PLT)

plasma prothrombin time (PT)

activated partial thromboplastin time (APTT)

interleukins-2 (IL-2)

IL-4

IL-10

tumor necrosis factor-

α

(TNF-

α

)

von willebrand factor (vWF)

platelet activating factor (PAF)

thrombomodulin (TM)

plasma fibrinogen (FIB)

urine RBC and urine protein (PRO) were detected.

Result:

2

The total clinical effect in observation group was 95.16%

which was higher than 81.54% in control group (

χ

2

=5.466

P

<

0.05). And the total symptoms of traditional Chinese medicine(TCM)was 96.77%

which was higher than 75% in control groups (

χ

2

=12.052

P

<

0.01). After treatment

levels of

β

2

-MG

24 h UmAlb

mAlb and CysC were higher than those in control groups (

P

<

0.01). And PT in both groups prolonged

particularly in observation group (

P

<

0.05). Level of FIB in observation group was lower than that in control groups (

P

<

0.05). And levels of IL-4

IL-10

TNF-

α

and vWF

PAF and TM were lower than those in control groups

but level of IL-2 was higher than that in control groups (

P

<

0.01).

Conclusion:

2

In addition to the hormone therapy

Jiawei Xijiao Dihuang Tang can protect renal function

relieve symptoms of proteinuria and hematuria

with the effects of resisting inflammation and alleviating coagulation function.