补骨脂的化学成分及主要毒性研究进展

魏蒙蒙; 王树瑶; 杨维; 李鹰飞; 李川

doi:10.13422/j.cnki.syfjx.20190517

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补骨脂的化学成分及主要毒性研究进展

综述 | 更新时间：2021-02-09

- 补骨脂的化学成分及主要毒性研究进展
- Chemical Constituents of Psoraleae Fructus and Its Main Toxic Ingredients
- 中国实验方剂学杂志 2019年25卷第7期页码：207-219
- 作者机构：
  
  中国中医科学院　中药研究所，北京　 100700
- 作者简介：
  
  魏蒙蒙，在读硕士，从事有毒中药药代动力学研究，Tel：010-56288129，E-mail：2546054880@qq.com
  李鹰飞，博士，副研究员，从事中药药代动力学研究，Tel：010-56288129，E-mail:yfli@icmm.ac.cn
- 基金信息：
  
  国家自然科学基金面上项目(81773990);国家“重大新药创制”科技重大专项(2015ZX09501004-003-005)
- DOI：10.13422/j.cnki.syfjx.20190517
  中图分类号： R284.1;R289;R22;R2-031
- 收稿日期：2018-10-17，
  
  网络出版日期：2018-11-21，
  
  纸质出版日期：2019-04-05
- 稿件说明：
移动端阅览
魏蒙蒙, 王树瑶, 杨维, 等. 补骨脂的化学成分及主要毒性研究进展[J]. 中国实验方剂学杂志, 2019,25(7):207-219.

Meng-meng WEI, Shu-yao WANG, Wei YANG, et al. Chemical Constituents of Psoraleae Fructus and Its Main Toxic Ingredients[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 207-219.
魏蒙蒙, 王树瑶, 杨维, 等. 补骨脂的化学成分及主要毒性研究进展[J]. 中国实验方剂学杂志, 2019,25(7):207-219. DOI： 10.13422/j.cnki.syfjx.20190517.

Meng-meng WEI, Shu-yao WANG, Wei YANG, et al. Chemical Constituents of Psoraleae Fructus and Its Main Toxic Ingredients[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(7): 207-219. DOI： 10.13422/j.cnki.syfjx.20190517.

摘要

补骨脂是豆科植物补骨脂的干燥成熟果实，性味辛、苦、温，归肾、脾经。补骨脂具有温肾助阳、纳气平喘、温脾止泻等功效，外用可消风祛斑，主要用于治疗肾阳不足所致阳痿遗精、腰膝冷痛、肾虚作喘、外用也可治疗白瘫风、斑秃。主要化学成分为香豆素类、单萜酚类、黄酮类，具有雌激素样作用以及抗炎、抗菌、抗真菌、抗氧化、抗肿瘤和免疫调节的活性，用于预防和治疗骨质疏松、细菌感染、哮喘和骨关节炎等。然而长期或大量服用补骨脂具有引发肝损伤的潜在危险，并有光毒性、肾毒性和生殖毒性，限制了其在临床中的应用。因此，充分了解补骨脂的化学成分谱，对全面掌握补骨脂致毒机制至关重要。通过对国内外关于补骨脂的文献查阅以及整理，该文对中药补骨脂的化学成分及其毒性研究进行系统综述，主要提供化合物的中英文名称，结构式，分子式，相对分子质量，CAS号以及近年来报道的关于补骨脂的毒性信息，为补骨脂后续的化学成分谱、药代、毒代动力学研究和补骨脂临床用药安全提供参考。

Abstract

Psoraleae Fructus (Buguzhi) is dried mature fruit of

Psoralea corylifolia

. It is spicy and bitter in favor and warm in nature

and distributed to kidney and spleen meridians. Psoralea Fructus has the effects of warming kidney and tonifying Yang

absorbing Qi and relieving asthma

warming spleen and stopping diarrhea; for external use

it can remove beverage. It is mainly used to treat impotence and nocturnal emission cold and knee pain

kidney deficiency and asthma caused by kidney Yang deficiency; for external use

it can treat vitiligo and alopecia areata. Its principle chemical components are coumarins

monoterpene phenols

flavonoids

with an estrogen-like effect as well as anti-inflammatory

antibacterial

antifungal

anti-oxidation

anti-tumor and immunomodulatory activities

and can be used for the prevention and treatment of osteoporosis

bacterial infections

asthma and osteoarthritis. However

the long-term administration with large doses of psoralen have the potential risk of causing liver damage

with phototoxicity

nephrotoxicity and reproductive toxicity

which restricts its application in clinical therapy. Therefore

it is essential to fully understand the chemical composition and mechanism of psoralen. Through the review and summarization of literatures about psoralen at home and abroad

this article systematically reviews the chemical constituents and toxicity of Psoralea Fructus

provides Chinese and English names

structural formulas

molecular formulas

molecular weights

CAS numbers of the compounds and the toxicity information about psoralen reported in recent years

in order to provide a reference for further study on the compositional spectrum and pharmacokinetics

toxic kinetic studies and clinical medication safety of psoralen.

关键词

Keywords

references

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