固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病患者的康复观察

桂坤; 杨俊; 龙启忠; 黄昱

doi:10.13422/j.cnki.syfjx.20190731

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固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病患者的康复观察

临床 | 更新时间：2021-02-09

- 固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病患者的康复观察
- Efficacy of Gushen Dingchuan Pills and Western Medicine in Treating Stable Chronic Obstructive Pulmonary Disease Patients with Syndrome of Lung and Kidney Qi Deficiency
- 中国实验方剂学杂志 2019年25卷第8期页码：89-94
- 作者机构：
  
  贵州医科大学　附属医院，贵阳　 550004
- 作者简介：
  
  桂坤，硕士，副教授，从事中西医呼吸病学的临床、科研及教学工作，E-mail: 13985583105@163.com
  杨俊，硕士，副主任医师，从事儿科临床、科研和教学工作，E-mail: ynanal@sina.com
- 基金信息：
  
  贵州省科技计划项目(黔科合LH字[2014]7133)
- DOI：10.13422/j.cnki.syfjx.20190731
  中图分类号： R25;R256;R256.1;R256.11
- 收稿日期：2018-08-17，
  
  网络出版日期：2018-12-06，
  
  纸质出版日期：2019-04-20
- 稿件说明：
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桂坤, 杨俊, 龙启忠, 等. 固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病患者的康复观察[J]. 中国实验方剂学杂志, 2019,25(8):89-94.

Kun GUI, Jun YANG, Qi-zhong LONG, et al. Efficacy of Gushen Dingchuan Pills and Western Medicine in Treating Stable Chronic Obstructive Pulmonary Disease Patients with Syndrome of Lung and Kidney Qi Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 89-94.
桂坤, 杨俊, 龙启忠, 等. 固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病患者的康复观察[J]. 中国实验方剂学杂志, 2019,25(8):89-94. DOI： 10.13422/j.cnki.syfjx.20190731.

Kun GUI, Jun YANG, Qi-zhong LONG, et al. Efficacy of Gushen Dingchuan Pills and Western Medicine in Treating Stable Chronic Obstructive Pulmonary Disease Patients with Syndrome of Lung and Kidney Qi Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 89-94. DOI： 10.13422/j.cnki.syfjx.20190731.

摘要

目的：

固肾定喘丸对稳定期肺肾气虚证慢性阻塞性肺疾病(COPD)的康复效果及对血清中S100钙结合蛋白A8/A9复合物(S100A8/A9)，核转录因子(NF)-

B，肿瘤坏死因子(TNF)-

，白细胞介素(IL)-8和IL-1

水平变化的影响。

方法：

选择110例COPD稳定期患者作为研究对象，参照数字表法随机分为对照组和治疗组各55例。对照组参照《慢性阻塞性肺疾病诊治指南(2013年修订版)》予常规治疗。治疗组在对照组治疗的基础上口服固肾定喘丸，1.5～2.0 g/次，3次/d。两组疗程均为连续治疗12周。比较两组患者肺功能、肺肾气虚证症状评分、生活质量圣乔治呼吸问卷(SGRQ)评分及临床疗效；检测两组血清S100A8/A9

NF-

TNF-

IL-8

IL-1

水平。

结果：

治疗后，治疗组患者第1秒用力肺活量占预计值百分比(FEV

%)和第1秒钟用力肺活量占用力肺活量的比值(FEV

/FVC)水平均显著高于对照组，肺肾气虚证评分明显低于对照组(

0.01)。治疗组患者的临床疗效总有效率96.15%，高于对照组总有效率80.39%(

=4.777，

0.05)；治疗组患者SGRQ量表评分均低于对照组(

0.01)；治疗组患者S100A8/A9和NF-

B水平均明显低于对照组(

0.01)；治疗组治疗后血清TNF-

，IL-8，IL-1

水平均明显低于对照组(

0.01)。

结论：

固肾定喘丸联合西医常规康复措施治疗稳定期肺肾气虚证COPD，可改善患者的肺功能、肺肾气虚证评分、生活质量，提高临床疗效，且可降低血中S100A8/A9和NF-

B等炎症因子水平。

Abstract

Objective:

To observe the efficacy of Gushen Dingchuan pills combined with routine western medicine in treating stable chronic obstructive pulmonary disease (COPD) patients with syndrome of lung and kidney Qi yin deficiency

and investigate its effect on serum levels of S100 calcium binding protein A8/A9 complex (S100A8/A9)

nuclear factor (NF)-

tumor necrosis factor (TNF)-

interleukin (IL)-8 and IL-1

Method:

One hundred and ten stable chronic COPD patients were selected and randomly divided into control group (55 cases) and treatment group (55 cases) by the random number table. Cases of control group received routine therapy by reference to the

Guidelines for Diagnosis and Treatment for Chronic Obstructive Pulmonary Disease

(2013

Revision

). In addition to the therapy of control group

cases of treatment group were orally given Gushen Dingchuan pills(1.5-2.0 g/time

tid

). Both groups were treated for 12 weeks. Lung function

scores of symptoms of lung and kidney Qi Yin deficiency

life quality St. George's respiratory questionnaire (SGRQ) score

and the efficacy were compared between both groups. Serum levels of S100A8/A9

NF-

TNF-

IL-8 and IL-1

were detected for two groups.

Result:

After treatment

FEV

% and FEV

/FVC of treatment group were obviously higher

while score of symptoms of lung and kidney Qi deficiency were lower than control group (

0.01). Total efficacy rate of observation group was 96.15%

which was evidently higher than 80.39%of control group (

=4.777

0.05). After treatment

score of SGRQ scale was lower than control group (

0.01). Serum levels of S100A8/A9 and NF-

B of treatment group were obviously lower than those of control group (

0.01). Serum levels of TNF-

IL-8

IL-1

of treatment group were remarkably lower than control group after treatment (

0.01).

Conclusion:

Gushen Dingchuan pills combined with western medicine can treat stable chronic COPD patients with syndrome of lung and kidney Qi Yin deficiency by improving lung function

alleviating symptoms of lung and kidney Qi deficiency

increasing life quality and efficacy and decreasing levels of S100A8/A9 and NF-

B inflammatory factors.

关键词

Keywords

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