大蒜降血脂作用及机制研究进展

胡斌; 匡海学; 辛运杰; 王雨笛; 王知斌; 姜海; 王秋红

doi:10.13422/j.cnki.syfjx.20190808

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大蒜降血脂作用及机制研究进展

综述 | 更新时间：2021-02-09

- 大蒜降血脂作用及机制研究进展
- Lipid-lowering Activity and Mechanism of Allii Sativi Bulbus
- 中国实验方剂学杂志 2019年25卷第8期页码：181-186
- 作者机构：
  
  1.黑龙江中医药大学　教育部北药基础与应用研究重点实验室，黑龙江省中药及天然药物药效物质基础研究重点实验室，哈尔滨　 150040;
  2.广东药科大学　中药学院，广州　 510006
- 作者简介：
  
  胡斌，在读博士，从事中药及复方药效物质基础研究，E-mail: hubin12332117@sina.com
  王秋红，博士，教授，从事中药炮制研究及中药药效物质基础和作用机制研究，Tel: 020-39353241，E-mail: qhwang668@sina.com
- 基金信息：
  
  国家自然科学基金项目(81773904)
- DOI：10.13422/j.cnki.syfjx.20190808
  中图分类号： R2-0;R22;R285.5;R284
- 收稿日期：2018-11-09，
  
  网络出版日期：2019-01-03，
  
  纸质出版日期：2019-04-20
- 稿件说明：
移动端阅览
胡斌, 匡海学, 辛运杰, 等. 大蒜降血脂作用及机制研究进展[J]. 中国实验方剂学杂志, 2019,25(8):181-186.

Bin HU, Hai-xue KUANG, Yun-jie XIN, et al. Lipid-lowering Activity and Mechanism of Allii Sativi Bulbus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 181-186.
胡斌, 匡海学, 辛运杰, 等. 大蒜降血脂作用及机制研究进展[J]. 中国实验方剂学杂志, 2019,25(8):181-186. DOI： 10.13422/j.cnki.syfjx.20190808.

Bin HU, Hai-xue KUANG, Yun-jie XIN, et al. Lipid-lowering Activity and Mechanism of Allii Sativi Bulbus[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 181-186. DOI： 10.13422/j.cnki.syfjx.20190808.

摘要

我国心血管疾病(CVD)防治工作已取得初步成效，但今后10年CVD患病人数仍将快速增长，从总体上看，中国CVD 患病率及死亡率仍处于上升阶段，CVD 负担日渐加重，已成为重大的公共卫生问题，防治CVD 刻不容缓。因此，开发安全、有效、廉价的CVD防治药物是一项具有重大意义的民生工程。大蒜是一种常用的药食两用中药材，资源丰富，应用历史悠久。自20世纪80年代以来，全球学者对大蒜进行了大量研究，结果表明大蒜具有降血脂、预防动脉粥样硬化、降血压、抗心肌缺血等防治心血管疾病的作用，以及抗肿瘤、抗菌、消炎、杀虫、调节机体免疫力、抗氧化、清除自由基等诸多药理活性。本文从大蒜调节血脂代谢入手，查阅国内外最新文献，基础研究和临床试验均表明大蒜具有良好的降血脂作用，其机制主要与抑制脂质合成过程的关键酶及调节脂质代谢的相关因子有关，本文就大蒜的降血脂作用及其分子机制进行综述，以期掌握其研究动向及研究中存在的问题，为大蒜的进一步研究和临床应用提供参考。

Abstract

Preliminary results have been achieved in the prevention and treatment of cardiovascular disease (CVD) in China

but the number of CVD patients will continue to grow rapidly in the next 10 years. Generally speaking

the prevalence and mortality of CVD in China are still on the rise. CVD has worsened and become a major public health problem. It is urgent to prevent CVD. Therefore

the development of safe

effective and inexpensive drugs for the prevention and treatment of CVD is a livelihood project of great significance. Allii Sativi Bulbus

as a commonly used medicinal and edible herbal medicine

has rich resources and a long history of application. Since the 1980s

many studies on Allii Sativi Bulbus have been carried out by global scholars. The results show that Allii Sativi Bulbus has the effects in reducing blood lipid

preventing atherosclerosis

lowering blood pressure

resisting myocardial ischemia and treating other cardiovascular diseases

with many pharmacological activities such as anti-tumor

anti-bacterial

anti-inflammatory

insecticidal

regulating immunity

anti-oxidation

free radical scavenging activities. Focusing on the regulation of blood lipid metabolism by Allii Sativi Bulbus

the latest literatures at home and abroad have been consulted. Both basic research and clinical trials have shown that Allii Sativi Bulbus has a good hypolipidemic effect. Its mechanism is mainly related to the inhibition of key enzymes in the process of lipid synthesis and related factors regulating lipid metabolism. In this paper

the hypolipidemic effect and molecular mechanism of garlic were reviewed to define its research trends and problems

and provide reference for further research and clinical application of Allii Sativi Bulbus.

关键词

Keywords

references

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