健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效

张亚利; 郭倩; 郑烈; 戴彦成; 唐志鹏

doi:10.13422/j.cnki.syfjx.20190829

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健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效

临床 | 更新时间：2021-02-09

- 健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效
- Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis
- 中国实验方剂学杂志 2019年25卷第10期页码：69-73
- 作者机构：
  
  1.上海中医药大学　附属龙华医院，上海　 200032；
  2.上海中医药大学　脾胃病研究所，上海　 200032；
  3.陕西省中医医院，西安　 710003；
  4.上海中医药大学　附属上海市中西医结合医院，上海　 200082
- 作者简介：
  
  张亚利，博士，副研究员，从事中医药防治胃肠疾病研究，E-mail：zhyl1999@163.com
  *郑烈，博士，主治医师，从事中医药防治胃肠疾病研究，E-mail: liezhenglie@126.com；
  *唐志鹏，博士，主任医师，教授，从事中医药防治胃肠疾病研究，E-mail: zhipengtang@sohu.com
- 基金信息：
  
  国家自然科学基金面上项目(81573892;81873253);国家自然科学基金青年基金项目(81704009);上海市卫生和计划生育委员会科研项目(201640122)
- DOI：10.13422/j.cnki.syfjx.20190829
  中图分类号： R22; R242; R2-031; R287
- 收稿日期：2018-09-25，
  
  网络出版日期：2019-01-04，
  
  纸质出版日期：2019-05-20
- 稿件说明：
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张亚利, 郭倩, 郑烈, 等. 健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效[J]. 中国实验方剂学杂志, 2019,25(10):69-73.

Ya-li ZHANG, Qian GUO, Lie ZHENG, et al. Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(10): 69-73.
张亚利, 郭倩, 郑烈, 等. 健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效[J]. 中国实验方剂学杂志, 2019,25(10):69-73. DOI： 10.13422/j.cnki.syfjx.20190829.

Ya-li ZHANG, Qian GUO, Lie ZHENG, et al. Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(10): 69-73. DOI： 10.13422/j.cnki.syfjx.20190829.

摘要

目的：

观察健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效评价。

方法：

选择并收集2012年4月1日至2014年1月31日在上海中医药大学附属龙华医院门诊及住院脾虚湿热型激素依赖UC患者60例，根据就诊顺序编号，采用随机数字表随机分为对照组和观察组各30例。两组患者均给予强的松基础治疗，对照组给予口服补脾益肠丸，6 g/次，3次/d。连续治疗3个月。观察组给予口服健脾清肠方，每日1剂，水煎300 mL，每次150 mL，2次/d，早晚分温服。连续治疗3个月。治疗后观察两组患者患者肠道症状积分、中医证候积分、内镜评分变化情况。

结果：

与本组治疗前比较，治疗后对照组腹泻、黏液脓血便症状积分均显著减少(

0.01)；观察组黏液脓血便、腹泻、腹痛、里急后重症状积分均显著减少(

0.01)，且观察组黏液脓血便、腹泻症状积分下降明显低于对照组(

0.05)。治疗前两组患者中医证候积分比较，差异无统计学意义；治疗后，两组患者中医证候积分均显著减少(

0.01)，且观察组减少较对照组明显(

0.05)。与本组治疗前比较，治疗后两组患者内镜评分均显著减少(

0.01)，且观察组下降较对照组显著(

0.01)。与本组治疗前比较，治疗后两组患者疾病活动指数(UCAI)，C反应蛋白(CRP)，血沉(ESR)指标及白细胞介素-8(IL-8)，肿瘤坏死因子-

(TNF-

)水平均降低(

0.05)，且治疗后治疗组较对照组明显降低(

0.05)。

结论：

健脾清肠方能有效改善脾虚湿热型激素依赖溃疡性结肠炎患者的黏液脓血便、腹泻症状，减少中医证候积分、内镜评分和降低炎症指标，值得临床借鉴推广。

Abstract

Objective:

To observe the clinical efficacy of Jianpi Qingchang decoction in the treatment of spleen deficiency and damp-heat hormone-dependent ulcerative colitis and explore its possible target.

Method:

A total of 60 patients with spleen deficiency and damp-heat hormone-dependent ulcerative colitis were selected and collected from the outpatient department and the inpatient department of Longhua Hospital affiliated to Shanghai University of Chinese Medicine on April 31

2012.Two groups were given the basic therapy of prednisone

and control group received orally bolus for spleen and spleen and intestines

6 g/time

3 times/d. The treatment continued for three months. The experimental group was given orally Jianpi Qingchang decoction

1 dose per day

and 300 mL water decoction

150 mL each time

2 times /d

and took at different temperatures in the morning and evening. The treatment continued for three months. After treatment

changes in intestinal symptom score

traditional Chinese medicine (TCM) syndrome score and endoscopic score of two groups were observed.

Result:

Compared with before treatment

the symptom scores of diarrhea

mucous purulent in control group were significantly reduced after treatment (

0.01). The scores of mucous purulent and bloody stool

diarrhea

abdominal pain

and tenesmus were significantly reduced in experimental group (

0.01)

and the scores of mucous purulent and bloody stool

and symptom of diarrhea were significantly decreased in experimental group after treatment than that of control group (

0.01). Before treatment

the scores of TCM syndromes in two groups were compared

with no statistically significant difference. After treatment

the scores of TCM syndromes of two groups were significantly reduced (

0.01)

and the reduction of the experimental group was more significant than that of control group (

0.05). Compared with before treatment

the endoscopy scores of two groups were significantly reduced after treatment (

0.01)

and the decrease of the experimental group was more significant than that of control group (

0.01). Mayo scores were significantly reduced in both groups after treatment compared with that before treatment (

0.01)

and significantly reduced in the experimental group compared with control group (

0.05).

Conclusion:

Jianpi Qingchang decoction can effectively improve mucous purulent stool and diarrhea symptoms in patients with spleen deficiency and damp-heat hormone-dependent ulcerative colitis

and reduce TCM syndrome score and endoscopic score

and thus is worthy of clinical reference and promotion.

关键词

Keywords

references

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