消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响

孙晓泽; 谭高峰; 刘爱华

doi:10.13422/j.cnki.syfjx.20190830

您当前的位置：

首页 >

文章列表页 >

消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响

经典名方 | 更新时间：2021-02-09

- 消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响
- Effect of Modified Xiaokefang on Endothelial Injury, Oxidative Stress and Biochemical Indices of Diabetic Nephropathy Patients of Qi-Yin Deficiency with Blood-stasis Syndrome
- 中国实验方剂学杂志 2019年25卷第9期页码：43-48
- 作者机构：
  
  河南省中医院，郑州　 450002
- 作者简介：
  
  孙晓泽，博士，主治医师，从事内分泌和代谢疾病的机制研究，E-mail：869970078@qq.com
- 基金信息：
  
  河南省二0一四年基础与前沿技术研究计划项目(142300410252)
- DOI：10.13422/j.cnki.syfjx.20190830
  中图分类号： R22; R242; R2-031; R287
- 收稿日期：2018-10-01，
  
  网络出版日期：2019-01-04，
  
  纸质出版日期：2019-05-05
- 稿件说明：
移动端阅览
孙晓泽, 谭高峰, 刘爱华. 消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响[J]. 中国实验方剂学杂志, 2019,25(9):43-48.

Xiao-ze SUN, Gao-feng TAN, Ai-hua LIU. Effect of Modified Xiaokefang on Endothelial Injury, Oxidative Stress and Biochemical Indices of Diabetic Nephropathy Patients of Qi-Yin Deficiency with Blood-stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 43-48.
孙晓泽, 谭高峰, 刘爱华. 消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响[J]. 中国实验方剂学杂志, 2019,25(9):43-48. DOI： 10.13422/j.cnki.syfjx.20190830.

Xiao-ze SUN, Gao-feng TAN, Ai-hua LIU. Effect of Modified Xiaokefang on Endothelial Injury, Oxidative Stress and Biochemical Indices of Diabetic Nephropathy Patients of Qi-Yin Deficiency with Blood-stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(9): 43-48. DOI： 10.13422/j.cnki.syfjx.20190830.

摘要

目的：

探究消渴方加减对气阴两虚夹瘀型糖尿病肾病(DN)的内皮损伤、氧化应激及生化指标的影响。

方法：

随机将2017年9月至2018年6月河南省中医院收治的94例DN患者分为两组，各47例，对照组采用静脉滴注还原型谷胱甘肽注射液进行治疗，在对照组的基础上，观察组给予消渴方加减进行治疗。于治疗前后，观察两组的症状评分、空腹血糖(FBG)，餐后2 h血糖(2 hPG)，谷胱甘肽过氧化物酶(GSH-Px)，超氧化物歧化酶(SOD)，丙二醛(MDA)，白细胞介素-1

(IL-1

)，IL-6，超敏C反应蛋白(hs-CRP)，肿瘤坏死因子-

(TNF-

)，组织型血纤维蛋白溶酶原激活物(t-PA)，1型组织纤溶酶原激活物抑制物(PAI-1)，血肌酐(SCr)，血尿素氮(BUN)，一氧化氮(NO)，内皮素-1(ET-1)，24 h尿总蛋白水平，并观察两组的疗效。

结果：

治疗后，观察组治疗总有效率为89.36%，高于对照组的74.47%(

＝3.949，

0.05)；观察组治疗后的口渴喜饮、倦怠乏力、气短、心悸、心烦、失眠、头晕耳鸣等中医症状评分低于对照组(

0.05)；观察组治疗后的FBG，2 hPG

SCr

BUN，24 h尿总蛋白，ET-1，MDA

IL-1

，IL-6，hs-CRP

TNF-

，PAI-1水平低于对照组(

0.05)，NO

SOD

GSP-Px

t-PA水平升高(

0.05)。

结论：

消渴方加减治疗气阴两虚夹瘀型DN效果显著，促进临床症状的改善，促进机体凝血纤溶系统平衡的恢复，抑制炎症反应及氧化应激反应，保护内皮功能及肾功能。

Abstract

Objective:

To explore the effect of modified Xiaokefang on endothelial injury

oxidative stress and biochemical indices of diabetic nephropathy(DN) patients of Qi-Yin deficiency with blood-stasis syndrome.

Method:

Ninety-four patients with DN admitted to our hospital from September 2017 to June 2018 were randomly divided into two groups. The control group (47 cases) was injected with reduced glutathione by intravenous drip. In addition to the therapy of the control group

the observation group (47 cases) was treated with modified Xiaokefang. Before and after treatment

the symptom scores

fasting blood glucose (FBG)

2 hpostprandial blood glucose (2 hPG)

glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)

malondialdehyde (MDA) and interleukin-1 beta (IL-1

)

IL-6

hypersensitive C-reactive protein (hs-CRP)

tumor necrosis factor-

(TNF-

)

tissue blood fibrin dissolve enzyme activation (t-PA)

type 1 original organization fibrin lytic enzyme activators inhibitor (PAI-1)

serum creatinine (SCr)

blood urea nitrogen (BUN)

nitric oxide (NO)

endothelin-1 (ET-1)

24 h total urinary protein levels were observed

and the efficacy of the two groups were observed.

Result:

After treatment

the total effective rate of the observation group was 89.36%

which was higher than 74.47%of the control group (

=3.949

0.05). The scores of symptoms in the observation group after treatment were lower than those in the control group (

0.05). After treatment

FBG

2 hPG

SCr

BUN

24 h total urine protein

ET-1

MDA

IL-1

IL-6

hs-CRP

TNF-

and PAI-1 levels in the observation group were lower than those in the control group (

0.05)

while NO

SOD

GSH-Px

and t-PA levels were increased (

0.05).

Conclusion:

Modified Xiaokefang has a remarkable effect in treatment of diabetic nephropathy patients of Qi-Yin deficiency with blood-stasis syndrome by alleviating clinical symptoms

promoting the recovery of balance of coagulation and fibrinolysis system

inhibiting inflammation and oxidative stress

and protecting endothelial function and renal function.

关键词

Keywords

references

FEI X , XING M , WO M , et al . Thyroid stimulating hormone and free triiodothyronine are valuable predictors for diabetic nephropathy in patient with type 2 diabetes mellitus [J]. Ann Transl Med , 2018 , 6 ( 15 ): 305 .

杨晓丹，巴应贵．糖尿病肾病发病机制的研究进展 [J]. 世界最新医学信息文摘， 2018 , 18 ( 51 ): 94 - 95 .

姜嫄嫄，王悦芬，李平．糖尿病肾病中医药诊治进展 [J]. 世界中医药， 2018 , 13 ( 6 ): 1315 - 1319 .

ZHAO Z . Correlation analysis of urine proteins and inflammatory cytokines with osteoporosis in patients with diabetic nephropathy [J]. J Musculoskelet Neuronal Interact , 2018 , 18 ( 3 ): 348 - 353 .

朱丽娜，张建伟．中医药治疗糖尿病肾病的进展 [J]. 中国中医药现代远程教育， 2018 , 16 ( 17 ): 154 - 156 .

郑小鹏，辛华．糖尿病肾病研究进展 [J]. 医学信息， 2018 , 31 ( 16 ): 26 - 29,37 .

林子桐，张超，沈雪梅．糖尿病肾病发病机制研究进展 [J]. 中国药理学与毒理学杂志， 2014 , 28 ( 5 ): 765 - 773 .

高超，李荣山．糖尿病肾病的药物治疗新进展 [J]. 临床医药实践， 2018 , 27 ( 5 ): 370 - 372 .

王琦，李小会．中医药治疗糖尿病肾病的研究进展 [J]. 现代中西医结合杂志， 2018 , 27 ( 23 ): 2619 - 2622 .

王倩，严美花，李平．糖尿病肾病中医证候的现代研究 [J]. 世界中医药， 2018 , 13 ( 6 ): 1320 - 1324,1331 .

中华医学会糖尿病学分会．中国2型糖尿病防治指南(2013年版) [J]. 中华内分泌代谢杂志， 2014 , 30 ( 10 ): 899 - 907 .

黎磊石，刘志红．中国肾脏病学 [M]．北京：人民军医出版社， 2008 ： 640 .

中华中医药学会肾病分会．糖尿病肾病诊断、辨证分型及疗效评定标准(试行方案) [J]. 上海中医药杂志， 2007 , 41 ( 7 ): 7 - 8 .

中华医学会糖尿病学分会微血管并发症学组．糖尿病肾病防治专家共识(2014年版) [J]. 中华糖尿病杂志， 2014 , 6 ( 11 ): 792 - 801 .

中华人民共和国卫生部．中药新药临床研究指导原则 [M]．北京：中国医药科技出版社， 2002 : 129-134,181-182 .

Agarwal S K , Saikia U K , Sarma D , et al . Assessment of glomerular and tubular function in the evaluation of diabetic nephropathy: a cross-sectional study [J]. Indian J Endocrinol Metab , 2018 , 22 ( 4 ): 451 - 456 .

仝小林，周强，赵林华，等．糖尿病肾病的中医辨治经验 [J]. 中华中医药杂志， 2014 , 29 ( 1 ): 144 - 146 .

赵延龙．中药黄芪的临床应用及药理作用分析 [J]. 中医临床研究， 2018 , 10 ( 11 ): 128 - 129 .

唐亚芳，杨岸新．中药川芎的有效成分及其药理作用研究 [J]. 中国现代药物应用， 2018 , 12 ( 10 ): 219 - 220 .

李娟，吴永胜，邱时秀，等．蚓激酶的最新研究进展 [J]. 四川畜牧兽医， 2017 , 44 ( 8 ): 34 - 35 .

ZHANG S , HUANG Q , WANG Q , et al . Enhanced renal afferent arteriolar reactive oxygen species and contractility to endothelin-1 are associated with canonical wnt signaling in diabetic mice [J]. Kidney Blood Press Res , 2018 , 43 ( 3 ): 860 - 871 .

Fawzy M S , Beladi F I A . Association of circulating Vitamin D, VDBP, and Vitamin D receptor expression with severity of diabetic nephropathy in a group of saudi type 2 diabetes mellitus patients [J]. Clin Lab , 2018 , 64 ( 10 ): 1623 - 1633 .

董静，于桂娜． ET/NO、t-PA/PAI-1及TXA_2/PGI_2与糖尿病肾病的关系 [J]. 山东医药， 2006 , 46 ( 16 ): 93 - 94 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

加味升降散对糖尿病肾病大鼠肾脏内质网应激和Sirt1/PERK通路的影响

藏族药灰兜巴下调Nox4表达减轻糖尿病肾病大鼠肾脏氧化应激损伤

肾康注射液辅助治疗早期糖尿病肾病的疗效及对氧化应激的影响

益肾化湿颗粒联合舒洛地特对早期老年糖尿病肾病氧化应激及内皮功能的影响