基于信号通路的中药有效成分治疗类风湿关节炎机制研究进展

王志强; 宫彩霞; 李振彬

doi:10.13422/j.cnki.syfjx.20190842

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基于信号通路的中药有效成分治疗类风湿关节炎机制研究进展

综述 | 更新时间：2021-02-09

- 基于信号通路的中药有效成分治疗类风湿关节炎机制研究进展
- Research Progress on Mechanism of Active Components of Traditional Chinese Medicine in Treating Rheumatoid Arthritis Based on Signaling Pathway
- 中国实验方剂学杂志 2019年25卷第8期页码：226-234
- 作者机构：
  
  1.中国人民解放军联勤保障部队第九八〇医院，石家庄　 050082；
  2.石家庄平安医院，石家庄　 050012
- 作者简介：
  
  王志强，在读博士，副主任医师，从事中西医结合风湿病学研究，E-mail: 1031448694@qq.com
  李振彬，博士，主任医师，博士生导师，从事中西医结合风湿病学研究，E-mail: 1040988746@qq.com
- 基金信息：
  
  河北省科技厅科研计划项目(142777103D)
- DOI：10.13422/j.cnki.syfjx.20190842
  中图分类号： G353.11;R932;R593.22;R684
- 收稿日期：2018-11-08，
  
  网络出版日期：2019-01-04，
  
  纸质出版日期：2019-04-20
- 稿件说明：
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王志强, 宫彩霞, 李振彬. 基于信号通路的中药有效成分治疗类风湿关节炎机制研究进展[J]. 中国实验方剂学杂志, 2019,25(8):226-234.

Zhi-qiang WANG, Cai-xia GONG, Zhen-bin LI. Research Progress on Mechanism of Active Components of Traditional Chinese Medicine in Treating Rheumatoid Arthritis Based on Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 226-234.
王志强, 宫彩霞, 李振彬. 基于信号通路的中药有效成分治疗类风湿关节炎机制研究进展[J]. 中国实验方剂学杂志, 2019,25(8):226-234. DOI： 10.13422/j.cnki.syfjx.20190842.

Zhi-qiang WANG, Cai-xia GONG, Zhen-bin LI. Research Progress on Mechanism of Active Components of Traditional Chinese Medicine in Treating Rheumatoid Arthritis Based on Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(8): 226-234. DOI： 10.13422/j.cnki.syfjx.20190842.

摘要

目的：

类风湿关节炎是最常见的炎性关节病之一，以滑膜组织增生、关节软骨进行性破坏为主要特征，与功能障碍和寿命缩短显著相关。药物治疗是类风湿关节炎的主要干预手段，但糖皮质激素和免疫抑制剂治疗存在副作用大、起效缓慢和疗效差等缺点，生物制剂治疗又存在价格昂贵的缺点。类风湿关节炎属中医“痹证”范畴，中医中药治疗类风湿关节炎历史悠久，具有疗效好、副作用小等优势，但其机制有待进一步研究。信号通路参与类风湿关节炎的发病和进展，是进行类风湿关节炎的病理机制及治疗药物的相关药理研究的主要靶点之一。近年来，针对中药有效成分对类风湿关节炎信号通路的调控作用开展了大量研究。这些信号通路包括Wnt信号通路，酪氨酸激酶(JAK)信号传导与转录活化因子(STAT)信号通路，丝裂原活化蛋白激酶(MAPK)信号通路，磷脂酰肌醇3激酶(PI3K)/丝氨酸/蛋白激酶B(Akt)信号通路，核转录因子-

B(NF-

B)信号通路，Toll样受体(TLRs)信号通路，细胞NF-

B受体活化因子配体(RANKL)/细胞NF-

B受体活化因子(RANK)/骨保护素(OPG)通路等。通过综述近年研究的成果，以期为类风湿关节炎的基础研究、新药开发及临床治疗提供思路和借鉴。

Abstract

Objective:

Rheumatoid arthritis (RA) is one of the most common inflammatory arthropathy diseases

characterized by synovium hyperplasia and progressive destruction of articular cartilage

which is significantly associated with dysfunction and shortening of life span. Drug therapy is the main intervention for RA

but the glucocorticoid and immunosuppressant have many shortcomings in treatment

such as great side effect

slow onset and poor efficacy

while biological agents are too expensive. RA belongs to the category of " arthralgia syndrome" in traditional Chinese medicine (TCM). TCM treatment for RA has a well-established history and multiple advantages such as good curative effect and less side effects

but its mechanism needs to be further studied. Signaling pathway is involved in the pathogenesis and progression of RA

so it is one of the main targets in research on the pathogenesis of RA and related pharmacological research of therapeutic drugs. In recent years

a large number of studies have been carried out on the regulation effect of active components of TCM on RA signaling pathways. These signaling pathways include Wnt signaling pathway

Janus tyrosine kinase (JAK)-signal transducers and transcription activator (STAT) signaling pathway

mitogen-activated protein kinase (MAPKs) signaling pathway

phosphoinositide-3-kinase (PI3K)/serine/protein kinase B (Akt) signaling pathway

nuclear factor-kappa B (NF-

B) signaling pathway

Toll like receptor (TLRs) signaling pathway

receptor activator of the nuclear factor kappa B ligand (RANKL)/receptor activator of the nuclear factor kappa B (RANK) / Osteoprotegerin (OPG) signaling pathway and so on. By reviewing the research results in recent years

we hope to provide ideas and reference for the basic research

development of new drugs and clinical treatment of RA.

关键词

Keywords

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