阴道黏膜给药系统的研究进展

王艳宏; 李洪晶; 杨柳; 关枫; 韩凤娟

doi:10.13422/j.cnki.syfjx.20190851

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阴道黏膜给药系统的研究进展

综述 | 更新时间：2021-02-09

- 阴道黏膜给药系统的研究进展
- Research Progress of Vaginal Mucosal Drug Delivery System
- 中国实验方剂学杂志 2019年25卷第17期页码：219-225
- 作者机构：
  
  1.黑龙江中医药大学　药学院，哈尔滨　 150040；
  2.黑龙江中医药大学　附属第一医院，哈尔滨　 150040
- 作者简介：
  
  王艳宏，博士，教授，从事中药经皮给药研究、中药药性理论研究，Tel：0451-87266893，E-mail：wang.yanhong@163.com
  韩凤娟，博士，教授，从事中西医结合治疗妇科肿瘤研究，Tel：0451-82119168，E-mail：hanfengjuan2004@163.com
- 基金信息：
  
  哈尔滨市应用技术研究与开发项目(2016RAXXJ047);黑龙江中医药大学研究生创新科研项目(yjscx2017058)
- DOI：10.13422/j.cnki.syfjx.20190851
  中图分类号： R22; R94; R28; G353.11; R711
- 收稿日期：2018-11-16，
  
  网络出版日期：2019-01-03，
  
  纸质出版日期：2019-09-05
- 稿件说明：
移动端阅览
王艳宏, 李洪晶, 杨柳, 等. 阴道黏膜给药系统的研究进展[J]. 中国实验方剂学杂志, 2019,25(17):219-225.

Yan-hong WANG, Hong-jing LI, Liu YANG, et al. Research Progress of Vaginal Mucosal Drug Delivery System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 219-225.
王艳宏, 李洪晶, 杨柳, 等. 阴道黏膜给药系统的研究进展[J]. 中国实验方剂学杂志, 2019,25(17):219-225. DOI： 10.13422/j.cnki.syfjx.20190851.

Yan-hong WANG, Hong-jing LI, Liu YANG, et al. Research Progress of Vaginal Mucosal Drug Delivery System[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 219-225. DOI： 10.13422/j.cnki.syfjx.20190851.

摘要

由于不仅可直达病灶部位而发挥局部治疗作用，还可避免肝脏首过效应而发挥全身治疗作用，阴道黏膜给药在阴道炎、宫颈炎等疾病的治疗和避孕等方面越来越受到国内外学者的关注。本文介绍了阴道的生理特点，探讨了影响药物吸收的因素；以美国食品药品监督管理局(FDA)，国家食品药品监督管理局(CFDA)药品数据库和2015年版《中国药典》收载的阴道黏膜给药上市制剂为研究对象，对其剂型、适应症等方面的应用情况进行了梳理和分析；查阅了近年来国内外有关阴道黏膜给药系统的相关文献，对其剂型和体内外评价进行了综述；指出了阴道黏膜给药制剂研究中存在的问题：①以西药制剂为主，相关的中药制剂开发较少，②剂型以片剂、栓剂、胶囊剂等常规剂型居多，③开展体内外评价的研究较少。提出阴道黏膜给药系统今后发展可在多种药物联合给药、高黏附性的辅料、脂质体等新技术、新方法的应用方面进行有益的尝试，以期为阴道黏膜给药系统的应用与完善提供参考。

Abstract

Because it can not only directly reach the lesion site to play a local therapeutic effect

but also avoid the liver first pass effect and play a systemic therapeutic effect

vaginal mucosal administration has attracted more and more attention from domestic and foreign scholars in the treatment of vaginitis

cervicitis and other diseases. This article introduces the physiological characteristics of the vagina and discusses the factors affecting drug absorption. The vaginal mucosal drug-administered preparations

which are contained in the drug database of U. S. Food and Drug Administration(FDA) and China Food and Drug Administration(CFDA)

and listed in the 2015 edition of

Chinese Pharmacopoeia

are taken as the research objects. And the application of their dosage forms

indications and other aspects were sorted out and analyzed. The related literature on vaginal mucosal drug delivery systems in recent years was reviewed

and the dosages forms and

in vitro

and

in vivo

evaluation were summarized. Some problems in the study of vaginal mucosal drug preparations have been pointed out: ①the western medicine preparations are widely used

and the related Chinese medicine preparations have been developed less; ②the majority of dosage forms are tablets

suppositories and other conventional dosage forms; ③there are few studies on the evaluation of vaginal mucosal preparations

in vitro

and

in vivo

. It is suggested that the future development of vaginal mucosal drug delivery system can be a useful attempt in the application of new technologies and methods

such as combination of drugs

high adhesion excipients

liposomes

etc; so as to provide reference for the application and improvement of vaginal mucosal drug delivery system.

关键词

Keywords

references

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