Objective:

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To analyze the medication rules of traditional Chinese medicine (TCM) in treating type 2 diabetes mellitus(T2DM)

and explore the mechanism of action.

Method:

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The articlesabout TCM treatment for T2DM in CNKI and Wanfang Med Online were retrieved. The data was entered into Excel 2013 to set up a database

and the factor analysis

association rules and cluster analysis were used to analyze core medication combinations by SPSS Statistics 19.0 and SPSS Modeler 14.1.kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis was performed using BATMAN-TCM to reveal the mechanism of action.

Result:

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A total of 92 prescriptions were included

the high frequency medicines were Astragali Radix.The major properties of TCM were cold and plain.The major flavors of TCM were sweet and bitter. The major meridian tropism of TCM was livermeridian. These high frequency medicines were deficiency-nourishing herbs

and blood circulation-invigorating and stasis-eliminating herbs. Totally 6 core medication combinations were mined through association rules. Seven common factors were extracted from factor analysis. Clustering analysis was used to get 6 kinds of herbs.KEGG pathway analysis revealed 24 biological pathways and 6 diseases relating to T2DM.

Conclusion:

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The most commonly used Astragali Radix for treating T2DM. In clinical

it can be combined with Poria

Salviae Miltiorrhizae Radix et Rhizoma and Rehmanniae Radix for treating T2DM. At the same time

it can be combined with such herbs as deficiency-nourishing herbs

and blood circulation-invigorating and stasis-eliminating herbs. The mechanism of action of high-frequency herbs may be related to the targets of exophosphatase/phosphodiesterase(PDEs)

adenosine A1 receptor gene 1(ADORA1)

adenosine A2A receptor gene(ADORA2A)

neuropetide second receptor(NPY2R)

and endothelial carbon monoxide synthase(NOS3) by interfering with PI3K/Akt

starch and sucrose metabolism signaling pathways.