溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策

叶天健; 马美娟; 钱帅; 高缘; 于明君; 魏元锋

doi:10.13422/j.cnki.syfjx.20190947

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溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策

综述 | 更新时间：2021-02-09

- 溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策
- Research Status, Problems and Countermeasures of Lyotropic Liquid Crystal in New Drug Delivery Systems of Traditional Chinese Medicine
- 中国实验方剂学杂志 2019年25卷第16期页码：229-234
- 作者机构：
  
  1.浙江永宁药业股份有限公司，浙江　台州　 318020；
  2.中国药科大学　中药学院，南京　 211198；
  3.东山街道社区卫生服务中心，南京　 211101
- 作者简介：
  
  叶天健，工程师，从事药物新制剂研究与开发工作，E-mail：78916980@qq.com
  魏元锋，博士，助教，从事中药制剂学研究，E-mail：weiyuanfengyuer@yeah.net
- 基金信息：
  
  国家自然科学基金项目(81703712);江苏省自然科学基金项目(BK20150703;BK20151438);中国药科大学“双一流”建设项目(CPU2018GY11;CPU2018GY28)
- DOI：10.13422/j.cnki.syfjx.20190947
  中图分类号： R22; R94; O753+ 2; R28; TB3; G353.11
- 收稿日期：2018-09-12，
  
  网络出版日期：2019-01-17，
  
  纸质出版日期：2019-08-20
- 稿件说明：
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叶天健, 马美娟, 钱帅, 等. 溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策[J]. 中国实验方剂学杂志, 2019,25(16):229-234.

Tian-jian YE, Mei-juan MA, Shuai QIAN, et al. Research Status, Problems and Countermeasures of Lyotropic Liquid Crystal in New Drug Delivery Systems of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 229-234.
叶天健, 马美娟, 钱帅, 等. 溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策[J]. 中国实验方剂学杂志, 2019,25(16):229-234. DOI： 10.13422/j.cnki.syfjx.20190947.

Tian-jian YE, Mei-juan MA, Shuai QIAN, et al. Research Status, Problems and Countermeasures of Lyotropic Liquid Crystal in New Drug Delivery Systems of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 229-234. DOI： 10.13422/j.cnki.syfjx.20190947.

摘要

溶致液晶(LLC)是由两亲性分子溶于极性溶剂中后相互缔结形成的具有各种几何形状或三维结构的有序体系，通常具有优异的载药适用性、较高的载药量、较好的生物黏附性及透皮促渗性等特点。笔者通过综合分析课题组前期对LLC给药系统的研究经验、成果以及相关研究报道，系统论述了LLC在中药新型给药系统领域，尤其是中药经皮及黏膜给药系统以及中药口服微粒给药系统方面的研究现状、研究价值以及开发潜力。由于目前中药领域LLC研究起步较晚，存在的诸多基础研究问题有待于进一步完善，该文对这些问题进行了归纳总结，并提出了相应研究对策：①基于对单一化学成分LLC的研究方法，结合中药自身特点，进一步加强对中药LLC给药系统的基础研究；②加强中药化学成分释药机制的研究，并进行同步缓释中药LLC给药系统的基础研究；③开发适用于中药的新型LLC材料；④完善中药LLC质量评价体系；⑤探索适用于产业化的LLC制备工艺。

Abstract

Lyotropic liquid crystal is an ordered system with various geometric shapes or three-dimensional structures formed by the interaction of amphiphilic molecules dissolved in polar solvents

and has the characteristics of excellent drug applicability

high drug loading

good bioadhesive property and high transdermal permeability. Through a comprehensive analysis of the research results in this research group and the related research reports of LLC drug delivery system

the authors systematically discussed the research value

development potential and research status of LLC in the field of new drug delivery system of traditional Chinese medicine(TCM)

especially in the percutaneous and mucosal drug delivery system and the oral microparticle drug delivery system of TCM. At the same time

due to the current research field of TCM-LLC drug delivery system starts late

many of the basic research problems to be further perfect

this paper had carried on the induction summary to these problems

and put forward the research countermeasures: ①the basic research of TCM-LLC drug delivery system should be strengthened by referencing the research experience and methods of LLC drug delivery system of single chemical component combined with TCM characteristics

②the research on the release mechanism of the chemical components in TCM should be strengthened

and the basic research on the LLC drug delivery system of synchronized sustained release TCM should be carried out

③development of new LLC materials applicable to TCM

④the quality evaluation system of TCM-LLC should be improved

⑤to explore the LLC preparation process suitable for industrialization.

关键词

Keywords

references

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