
浏览全部资源
扫码关注微信
1.成都中医药大学 民族医药学院,成都 611137;
2.西藏藏医药大学,拉萨 850000;
3.海西州蒙藏医医院,青海 德令哈 817000
文成当智,在读博士,从事藏药药性与信息化研究,E-mail:wenchengdangzhi@aliyun.com
张艺,博士,研究员,从事民族药药效物质基础和民族医药信息化研究,E-mail:zhangyi@cdutcm.edu.cn
收稿日期:2018-11-23,
网络出版日期:2019-01-17,
纸质出版日期:2019-10-05
移动端阅览
文成当智, 贡保东知, 贡却拉姆, 等. 藏族药药性量化的新方法——“味性化味”矢量结构模型构建[J]. 中国实验方剂学杂志, 2019,25(19):147-154.
Dang-zhi WENCHENG, Dong-zhi GONGBAO, La-mu GONGQUE, et al. A New Quantitative Method of Tibetan Medicine Property——Construction of " Ro Nus ZhurJes" Vector Structural Model[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 147-154.
文成当智, 贡保东知, 贡却拉姆, 等. 藏族药药性量化的新方法——“味性化味”矢量结构模型构建[J]. 中国实验方剂学杂志, 2019,25(19):147-154. DOI: 10.13422/j.cnki.syfjx.20190952.
Dang-zhi WENCHENG, Dong-zhi GONGBAO, La-mu GONGQUE, et al. A New Quantitative Method of Tibetan Medicine Property——Construction of " Ro Nus ZhurJes" Vector Structural Model[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 147-154. DOI: 10.13422/j.cnki.syfjx.20190952.
“味性化味”(Ro Nus ZhurJes)理论是藏族药(简称藏药)药性理论的核心内容,也是藏药核心配伍规律,是以药物的六味为表层药性,被三胃火消化后的三化味为内层药性,八性和十七效等为深层药性,本质性能为特殊药性,形成多层次药性理论,但其内在结构仍需统一整理,临床实用性有待进一步提高。该文采用文献挖掘,藏药理论,矢量结构模型,K-均值聚类分析,Gephi 0.9.2可视化软件等方法,整理藏药药性理论,发现藏药药性内在结构具有“7
药性
+3
特性
”的多维结构特点,且药性相同则会叠加,药性相反则会抵消,可用矢量表示,提出了构建藏药“味性化味”矢量结构模型。以二十五味余甘子散和92种常用藏药方剂为例,分析单一方剂十七效和多个方剂作用于三因的比值,并将其结果与临床功效进行对比验证,结果发现模型分析结果与临床功效之间不仅从方剂的六味、三化味、十七效等高度吻合,而且主治疾病等均相符,具有很高的拟合度和解释度,能够有效而直观地量化藏药方剂药性,揭开复杂的藏药理论隐性知识。后续将继续应用藏药“味性化味”矢量结构模型分析藏医经典方剂,并不断进行拟合评价及修正优化,以期提高藏药药性理论在大数据环境下的实用性,为藏药方剂的药性量化提供方法学参考。
" Ro Nus ZhurJes" theory is the core content of Tibetan medicine property theory
and also the core compatibility law of Tibetan medicine. It takes six tastes of medicine as the surface medicinal property
three tastes after digestion by " three gastropyretie" as the inner medicinal property
eight properties and seventeen effects as the deep medicinal property
and its essential property is the special medicinal property
forming a multi-level medicinal property theory
but its internal structure still needs to be unified and sorted out
clinical practicability needs to be further improved. In this paper
literature mining
Tibetan medicine theory
vector structural model
K-means clustering analysis
Gephi 0.9.2 visualization and other methods were used to sort out the theory of Tibetan medicinal properties. It was found that the inherent structure of Tibetan medicine properties had the multi-dimensional structural characteristics of " seven medicinal properties+ three characteristics"
and that the same medicinal properties would overlap
while the opposite medicinal properties would offset and could be expressed by vectors. Therefore
the vector structural model of " Ro Nus ZhurJes" of Tibetan medicine was proposed in this paper. Taking twenty-five-flavor Yuganzi powder(skyu-ru-nyer-lnga) and 92 commonly used Tibetan medicine prescriptions as examples
the rates of single prescription with seventeen effects and multiple prescriptions acting on three factors were analyzed. The model analysis results were highly consistent with the clinical efficacy
and the main diseases were the same
which showed that this model had a high degree of fitting and interpretation. It could effectively and intuitively quantify the properties of Tibetan medicine prescriptions and uncover the complex hidden knowledge of Tibetan medicine theory. In the future
the vector structural model of " Ro Nus ZhurJes" will be applied to analyze the classical prescriptions of Tibetan medicine
and the fitting evaluation and modification optimization will be carried out continuously in order to improve the practicability of theory of Tibetan medicine property in the big data environment and provide methodological reference for the quantification of medicinal property of Tibetan medicine prescriptions.
蒋俊 , 贾晓斌 , 陈斌 , 等 . 基于组分结构假说构建中药药性矢量结构方程 [J]. 中草药 , 2012 , 43 ( 3 ): 422 - 427 .
Lu I R R , Kwan E , Thomas D R , et al . Two new methods for estimating structural equation models: an illustration and a comparison with two established methods [J]. Int J Res Mark , 2011 , 28 ( 3 ): 258 - 268 .
青海省藏医药研究所 , 《藏医药经典文献集成》编委会 . 八支精要自释 [M]. 藏文版 . 北京 : 民族出版社 , 2006 : 119 - 691 .
宇妥·云丹贡布 . 四部医典 [M]. 藏文版 . 拉萨 : 西藏人民出版社 , 1982 : 66 - 68 .
《藏医药经典文献集成》编委会 , 青海省藏医药研究所 . 金巴四部医典注释 [M]. 藏文版 . 北京 : 民族出版社 , 2006 : 379 - 382 .
文成当智 . 藏药药理数据挖掘方法研究 [D]. 西宁 : 青海大学 , 2016 .
帝玛尔·丹增彭措 . 晶珠本草 [M]. 北京 : 民族出版社 , 2005 : 3-4,34-45 .
文成当智 , 仁增多杰 , 才让南加 , 等 . 藏药“棏嗒杰巴”的味功效 [J]. 中国民族民间医药 , 2015 , 24 ( 4 ): 4 - 5 .
中华人民共和国卫生部 . 药品标准·藏药 [M]. 北京 : 中华人民共和国卫生部药典委员会 , 1998 : 34 - 76 .
云丹嘉措 . 藏医临床札记 [M]. 西宁 : 青海民族出版社 , 2013 : 33 - 41 .
刘力红 . 思考中医 [M]. 南宁 : 广西师范大学出版社 , 2002 : 21 - 24 .
文成当智 , 贡保东知 , 东改措 , 等 . 《四部医典》用药规律——“味性化味”理论的科学内涵分析 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 5 ): 201 - 207 .
李佼阳 , 付先军 , 李学博 , 等 . 不同归经中药在生物系统发育树的分布规律及关联关系分析 [J]. 中国实验方剂学杂志 , 2017 , 23 ( 12 ): 194 - 200 .
管冬元 , 方肇勤 , 潘志强 , 等 . 中药五味标准化检验方法的建立 [J]. 中国中医基础医学杂志 , 2011 , 17 ( 12 ): 1333 - 1335 .
文成当智 , 尕玛措尼 , 斗周才让 , 等 . 藏医五源学说与现代物理学认识物质本质的哲学思考 [J]. 中华中医药杂志 , 2017 , 32 ( 4 ): 1483 - 1485 .
杨宏博 , 苏敏 , 刘慧浪 , 等 . 基于生物热动力学的黄连不同提取部分抑菌活性分析 [J]. 中国实验方剂学杂志 , 2017 , 23 ( 16 ): 51 - 56 .
0
浏览量
16
下载量
9
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621