Objective:

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To investigate the compatible stability of Xingnaojing injection in combination with 9 common medicines

and to provide a reference for clinical application of this injection.

Method:

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According to the clinical application

Xingnaojing injection was mixed with 9 common medicines and placed in the room under dark and light conditions for 6 h. The appearance of compatible solutions was observed

and the HPLC fingerprint was analyzed by similarity evaluation and principal component analysis(PCA).

Result:

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There were no significant changes in the appearance of compatibility of Xingnaojing injection and 9 common medicines

including piracetam and sodium chloride injection

sodium chloride injection and others. The similarities of fingerprint among compatibility of Xingnaojing injection and 9 common medicines were >0.98 at 0 h of compatibility

6 h of placement and 6 h of illumination. The results of PCA showed that 9 groups of compatible solutions were clustered into 2 categories

the compatibility of Xingnaojing injection and 8 groups including piracetam and sodium chloride injection clustered into one category

and the relative peak areas of the characteristic components of Xingnaojing injection did not change significantly after compatibility

the compatibility of Xingnaojing injection and Danshen Chuanxiongqin injection clustered into another category

the relative peak areas of some characteristic components of Xingnaojing injection increased after compatibility of 0 h and 6 h

and it was more obvious after 6 h of illumination.

Conclusion:

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The compatibility of Xingnaojing injection and 8 common medicines including piracetam and sodium chloride injection has good stability

while the compatibility has stability problems after Xingnaojing injection mixed with Danshen Chuanxiongqin injection. It is suggested that clinical attention should be paid to their compatibility and rational combination of medicines.