小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响

方旭仙; 王有成; 朱璐卡; 姚静婵; 胡国华

doi:10.13422/j.cnki.syfjx.20191123

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小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响

临床 | 更新时间：2021-02-09

- 小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响
- Clinical Efficacy of Xiaoer Anorexia Granule Combined with Saccharomyces Brassicus in Treatment of Pediatric Anorexia and Its Effect on Serum Cytokines
- 中国实验方剂学杂志 2019年25卷第12期页码：115-120
- 作者机构：
  
  1.金华市人民医院，浙江　金华　 321000；
  2.义乌市中心医院，浙江　义乌　 322000；
  3.金华职业技术学院　医学院，浙江　金华　 321017
- 作者简介：
  
  方旭仙，主治医师，从事小儿消化系统疾病的研究，E-mail：0579210892@qq.com
  胡国华，主任医师，从事小儿消化系统疾病的研究，E-mail：ghh53021@163.com
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191123
  中图分类号： R22; R242; R2-031; R272; R287
- 收稿日期：2018-10-30，
  
  网络出版日期：2019-02-20，
  
  纸质出版日期：2019-06-20
- 稿件说明：
移动端阅览
方旭仙, 王有成, 朱璐卡, 等. 小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响[J]. 中国实验方剂学杂志, 2019,25(12):115-120.

Xu-xian FANG, You-cheng WANG, Lu-ka ZHU, et al. Clinical Efficacy of Xiaoer Anorexia Granule Combined with Saccharomyces Brassicus in Treatment of Pediatric Anorexia and Its Effect on Serum Cytokines[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 115-120.
方旭仙, 王有成, 朱璐卡, 等. 小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响[J]. 中国实验方剂学杂志, 2019,25(12):115-120. DOI： 10.13422/j.cnki.syfjx.20191123.

Xu-xian FANG, You-cheng WANG, Lu-ka ZHU, et al. Clinical Efficacy of Xiaoer Anorexia Granule Combined with Saccharomyces Brassicus in Treatment of Pediatric Anorexia and Its Effect on Serum Cytokines[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 115-120. DOI： 10.13422/j.cnki.syfjx.20191123.

摘要

目的：

探讨小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症的临床疗效及对血清细胞因子的影响。

方法：

选取金华市人民医院2015年10月至2017年10月收治的小儿厌食症患儿240例，随机分为3组，各80例，联合组服用小儿厌食颗粒，l～3岁，1包/次；4～6岁，2包/次，每天3次口服，联合布拉氏酵母菌0.5 g/次，2次/d，饭前15～30 min口服。布拉氏酵母菌组单独服用布拉氏酵母菌，方法同联合组。小儿厌食颗粒组单独服用小儿厌食颗粒，方法同联合组。8周为1个疗程。同时检测3组血清细胞因子血清瘦素(Leptin)，P物质(SP)和促人生长激素腺释放肽(Ghrelin)。观察两组临床疗效、体质量与身高改善情况和血清细胞因子水平变化。

结果：

联合组总好转率91.25%，显著高于布拉氏酵母菌组的71.25%与小儿厌食颗粒组的73.75%(

0.01)；联合组总有效率95.00%，显著高于布拉氏酵母菌组的71.25%与小儿厌食颗粒组的70.00%(

0.01)；治疗8周后，联合组患儿Leptin水平较布拉氏酵母菌、小儿厌食颗粒组降低更显著(

0.01)。联合组患儿SP及Ghrelin水平较布拉氏酵母菌，小儿厌食颗粒组上升更显著(

0.01)，但上述细胞因子布拉氏酵母菌组和小儿厌食颗粒组比较差异无统计学意义。对3组治疗有效者进行6个月随访(剔除失访者)，治疗前3组体质量与身高比较差异无统计学意义，治疗后3组体质量与身高均较本组治疗前增加(

0.05，

0.01)，联合组显著优于布拉氏酵母菌和小儿厌食颗粒组(

0.01)，布拉氏酵母菌、小儿厌食颗粒组比较差异无统计学意义。

结论：

小儿厌食颗粒联合布拉氏酵母菌治疗小儿厌食症能提高临床总有效率，调整血清细胞因子水平，增加身高与体质量。

Abstract

Objective:

To investigate the clinical efficacy of Xiaoer anorexia granule combined with

Saccharomyces brassicus

in the treatment of infantile anorexia and its effect on serum cytokines.

Method:

Totally 240 cases of infantile anorexia treated in Jinhua People's Hospital from October 2015 to October 2017 were randomly divided into three groups. Group A (combination group) orally took Xiaoer anorexia granule

1 pack/time for 1-3 years old

2 packs/time for 4-6 years old

3 times a day

and combined with saccharomyces brasiliensis

0.5 g/time

2 times a day

15-30 min before meal. Group B took saccharomyces brasiliensis by the same method as the combination group. Group C took Xiaoer anorexia granules by the same method as above

with 80 cases in each group. 8 weeks is a course of treatment. Serum inflammatory cytokines leptin

SP and Ghrelin were also detected. The clinical efficacy

body weight

height improvement and serum cytokine levels were observed in 3 groups.

Result:

The total improvement rate of group A was 91.25%

which was significantly higher than 71.25%of group B and 73.75%of group C

with statistically significant differences (

0.01). The total effective rate of group A was 95.00%

which was significantly higher than 71.25%of group B and 70.005%of group C

with statistically significant differences (

0.01). After 8 weeks of treatment

the serum leptin level in group A was significantly lower than that in group B and group C (

0.01). The levels of serum SP and Ghrelin in group A were higher than those in group B and C (

0.01). However

there was no significant difference in cytokine between group B and group C. The 3 groups of patients who received effective treatment were followed up for 6 months (excluding missing cases). There was no significant difference in body weight and height among three groups before treatment. After treatment

the body weight and height of three groups were higher than those before treatment (

0.05

0.01). However

group A was superior to group B and group C (

0.01). There was no significant difference between group B and group C.

Conclusion:

Treatment of infantile anorexia with Xiaoer anorexia granules combined with Saccharomyces cerevisiae can improve the total clinical effective rate

adjust serum cytokine levels and increase height and body mass.

关键词

Keywords

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