何首乌中相关蒽醌类化合物抗癌作用的研究进展

朱艺; 李琛; 李洪亮; 汪选斌

doi:10.13422/j.cnki.syfjx.20191228

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何首乌中相关蒽醌类化合物抗癌作用的研究进展

综述 | 更新时间：2021-02-09

- 何首乌中相关蒽醌类化合物抗癌作用的研究进展
- Anti-cancer Effect of Anthraquinones in Polygoni Multiflori Radix
- 中国实验方剂学杂志 2019年25卷第18期页码：196-205
- 作者机构：
  
  1.湖北中医药大学，武汉　 430061；
  2.十堰市人民医院(湖北医药学院　附属人民医院)，湖北　十堰　 442000；
  3.湖北医药学院　生物医药研究院，武当特色中药研究湖北省重点实验室，湖北　十堰　 442000
- 作者简介：
  
  朱艺，在读硕士，从事中药抗肿瘤药理学研究，E-mail：137562213@qq.com
  汪选斌，博士，教授，从事中药抗肿瘤药理学研究，E-mail：wangxb@hbmu.edu.cn
- 基金信息：
  
  国家自然基金面上项目(81874356);湖北省卫计委重点项目(WJ2017Z023);湖北省高等学校优秀中青年科技创新团队计划项目(T201510);湖北省学科建设项目及湖北医药学院重点学科建设项目(2014XKJSXJ18;2018YHKT01);湖北医药学院优秀中青年团队项目(2014CXG03;2014CXZ01)
- DOI：10.13422/j.cnki.syfjx.20191228
  中图分类号： R22; R242; R2-031; R287;R285.5
- 收稿日期：2018-10-15，
  
  网络出版日期：2019-03-04，
  
  纸质出版日期：2019-09-20
- 稿件说明：
移动端阅览
朱艺, 李琛, 李洪亮, 等. 何首乌中相关蒽醌类化合物抗癌作用的研究进展[J]. 中国实验方剂学杂志, 2019,25(18):196-205.

Yi ZHU, Chen LI, Hong-liang LI, et al. Anti-cancer Effect of Anthraquinones in Polygoni Multiflori Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(18): 196-205.
朱艺, 李琛, 李洪亮, 等. 何首乌中相关蒽醌类化合物抗癌作用的研究进展[J]. 中国实验方剂学杂志, 2019,25(18):196-205. DOI： 10.13422/j.cnki.syfjx.20191228.

Yi ZHU, Chen LI, Hong-liang LI, et al. Anti-cancer Effect of Anthraquinones in Polygoni Multiflori Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(18): 196-205. DOI： 10.13422/j.cnki.syfjx.20191228.

摘要

目的：

何首乌是蓼科多年生缠绕藤本植物何首乌

Polygonum multiflorum

的干燥块根，2015年版《中国药典》根据其加工方法不同分为生何首乌(Polygoni Multiflori Radix)和制何首乌(Polygoni Multiflori Radix Praparata)。该综述总结了何首乌中相关蒽醌类化合物的抗癌作用，为探讨何首乌的抗癌作用活性物质基础和作用机制研究奠定基础。

方法：

依据网络数据库PubMed，CNKI，重庆维普等相关文献，对近15年来关于何首乌中相关蒽醌类化学成分及药理作用等研究成果进行汇总分析。

结果：

何首乌中相关蒽醌类化合物有20种。与其他蓼科植物相比，2015年版《中国药典》规定的何首乌质量标记物大黄素和大黄素甲醚含量较高。在抗癌作用方面，诱导癌细胞凋亡的有大黄素及其大黄素-8-

-葡萄糖苷、芦荟大黄素、大黄酚、大黄素甲醚及其大黄素甲醚-8-

-葡萄糖苷、大黄酸；抑制细胞周期的有大黄素、芦荟大黄素、大黄酚、大黄素甲醚、大黄酸；抑制细胞迁移、侵袭和转移的有大黄素、芦荟大黄素、大黄素甲醚及其大黄素甲醚-8-

-葡萄糖苷；阻断能量代谢者有大黄素、大黄酚、大黄酸；逆转肿瘤多药耐药的有大黄素。

结论：

何首乌相关蒽醌类化合物具有潜在的抗癌药用价值，其作用机制、成分之间的相互作用等有待深入研究。

Abstract

Objective:

Polygoni Multiflori Radix is the drought root of a perennial vine

Polygonum multiflorum

which is belong to Polygonaceae. According to

Chinese Pharmacopeia

(edition 2015)

its preparations are divided into two types based on the processing: crude Polygoni Multiflori Radix

and processed Polygoni Multiflori Radix Praparata. This study aimed to explore the substantial bases

effect and the mechanisms of anthraquinones in Polygoni Multiflori Radix.

Method:

Based on the literatures retrieved in PubMed

CNKI and Chongqing VIP in past 15 years

the chemical composition

pharmacological effects and mechanisms of anthraquinones in Polygoni Multiflori were reviewed and summarized.

Result:

There were 20 anthraquinones in Polygoni Multiflori. Compared with other

Polygonaceae

plants

there were higher contents of emodin and physcion

both were qualification markers in Polygoni Multiflori. In terms of the anti-cancer effect

emodin

emodin-8-

-glucoside

aloe-emodin

chrysophanol

physcion

physcion-8-

-glucoside and rhein induced cancer cell apoptosis. Emodin

aloe-emodin

chrysophanol

physcion and rhein inhibited cancer cell cycles. Emodin

aloe-emodin

physcion and emodin-8-

-glucoside blocked migration

invasion and metastasis. And emodin

chrysophanol and rhein blocked energy metabolism

and emodin reversed multidrug resistance in cancer.

Conclusion:

Polygoni Multiflori may play a potential anti-cancer value

and its underlying mechanisms and the interaction between components are worth of further studies.

关键词

Keywords

references

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