中药挥发油抗白血病机制及问题探讨

邓锦松; 张海燕; 杨启悦; 吴升星; 汪镇朝; 李艳

doi:10.13422/j.cnki.syfjx.20191229

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中药挥发油抗白血病机制及问题探讨

综述 | 更新时间：2021-02-09

- 中药挥发油抗白血病机制及问题探讨
- Anti-leukemia Mechanism and Problems of Volatile Oil from Traditional Chinese Medicine
- 中国实验方剂学杂志 2019年25卷第19期页码：226-234
- 作者机构：
  
  1.江西中医药大学　现代中药制剂教育部重点实验室，固体制剂工程中心，南昌　 330004；
  2.成都中医药大学　附属医院，成都　 610075
- 作者简介：
  
  邓锦松，在读硕士，从事中药新剂型研究，E-mail: djs86882591@163.com
  张海燕，博士，副教授，从事新药研发工作，E-mail：haiyansl@163.com；
  杨启悦，硕士，主治医师，从事内分泌及代谢性相关疾病临床工作及研究，E-mail：ruozi0920@163.com
- 基金信息：
  
  江西省教育厅科学技术研究项目(GJJ180638)
- DOI：10.13422/j.cnki.syfjx.20191229
  中图分类号： R22; R242; R2-031; R287;R285.5
- 收稿日期：2018-10-09，
  
  网络出版日期：2019-03-04，
  
  纸质出版日期：2019-10-05
- 稿件说明：
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邓锦松, 张海燕, 杨启悦, 等. 中药挥发油抗白血病机制及问题探讨[J]. 中国实验方剂学杂志, 2019,25(19):226-234.

Jin-song DENG, Hai-yan ZHANG, Qi-yue YANG, et al. Anti-leukemia Mechanism and Problems of Volatile Oil from Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 226-234.
邓锦松, 张海燕, 杨启悦, 等. 中药挥发油抗白血病机制及问题探讨[J]. 中国实验方剂学杂志, 2019,25(19):226-234. DOI： 10.13422/j.cnki.syfjx.20191229.

Jin-song DENG, Hai-yan ZHANG, Qi-yue YANG, et al. Anti-leukemia Mechanism and Problems of Volatile Oil from Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 226-234. DOI： 10.13422/j.cnki.syfjx.20191229.

摘要

白血病(leukemia)是一种发病率逐年增高的造血系统恶性增生性疾病，包括骨髓和淋巴系统。其病情复杂，是一种高度异质性的疾病，包括多种亚型，治疗难度大，预后欠佳。当前临床上常用于治疗白血病细胞分化诱导剂的有维甲酸及其衍生物、砷剂等，但他们治疗的临床范围多局限于粒系白血病，价格昂贵，而且仍有一定的毒副作用。随着分子遗传学、分子生物学、二代测序等技术的发展，对白血病的病因学、病理学的认识已有明显的提高，但是白血病具体的发病机制仍未能明确。随着分子靶向药物和嵌合抗原受体T细胞免疫疗法(chimeric antigen receptor T-cell immunotherapy，CAR-T)及造血干细胞移植的进一步推广，虽然使白血病的治疗进入了新领域，但是与传统化疗相比除了治疗成本高外，长期疗效还有待于进一步确认。经过多年的基础研究及临床研究发现，中药挥发油在治疗白血病领域取得了显著成就。中药挥发油不仅可以减轻化疗药物带来的毒副作用，而且能有效的延长或阻止白血病复发、抑制白血病细胞增殖和促进白血病细胞凋亡的优势。本文通过文献追踪法查阅了国内外相关文献，对中药挥发油抗白血病机制进行概述，分析了中药挥发油的特点及存在问题，并提出了改进的方向，为加快中药挥发油治疗白血病的研发和创新提供参考。

Abstract

Leukemia is a hematopoietic hyperplastic disease with an increasing incidence year by year

involving bone marrow and lymphatic system. The disease is complex and a highly heterogeneous disease

including a variety of subtypes

with difficulties in treatment and a poor prognosis. Currently

retinoic acid and its derivatives

arsenic are commonly used in clinical treatment as leukemia cell differentiation inducers. However

their clinical range of treatment is mostly restricted to granulocytic leukemia

with a high price and certain toxic and side effects. With the development of molecular genetics

molecular biology

second-generation sequencing and other technologies

the etiology and pathology of leukemia has been significantly studied

but the specific pathogenesis of leukemia has still been unclear. With the further promotion of molecular targeted drugs

chimeric antigen receptor T-cell immunotherapy (CAR-T) and hematopoietic stem cell transplantation

although the treatment of leukemia has entered a new field

compared with traditional chemotherapy

these therapies have high costs

and the long-term efficacy is yet to be further confirmed. After years of basic research and clinical research

traditional Chinese medicine(TCM) volatile oil in the treatment of leukemia has made remarkable achievements. Essential oil can alleviate the toxic and side effect of chemotherapy drugs

effectively prolong or prevent the relapse of leukemia

inhibit the proliferation of leukemia cells

and promote the apoptosis of leukemia cells. In this paper

the authors reviewed relevant domestic and foreign literatures by literature tracking method

summarized the anti-leukemia mechanism of essential oil of TCM

analyzed the characteristics and existing problems of essential oil of TCM

and proposed the improvement direction

in order to provide reference for accelerating the research and development and innovation of essential oil in the treatment of leukemia.

关键词

Keywords

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