Objective:

2

To observe the clinical effect of modified Huangqi Guizhi Wuwu Tang on patient with lower-extremity arterial disease (LEAD) with deficiency of Qi and Yin and blood stasis syndrome

and study the antioxidant mechanism.

Method:

2

One hundred and twenty-eight patients were randomly divided into control group (64 cases) and observation group (64 cases) by random number table. Patients in control group was treated for controlling blood sugar

blood pressure and blood fat

and got probucol in the morning and evening

0.5 g/time

2 times/days

aspirin enteric-coated tablets for 3 months

100 mg·d

-1

and alprostadil injection diluted with 10 mL normal saline for 15 days

10 μg·d

-1

1 time/day. A course of the treatment in control group was 15 days

and there were 4 courses. In addition to the therapy of control group

patients in observation group were additionally given modified Huangqi Guizhi Wuwu Tang

1 dose/day

for 3 months. Before and after treatment

ankle brachial index (ABI) and toe branch index (TBI) were detected

and internal diameter of dorsal artery of foot

peak velocity and blood flow were detected by color Doppler ultrasound. Main symptoms and sign were scored. And levels of interleukin-1 (IL-1)

Homocysteine (Hcy)

tumor necrosis factor-

α

(TNF-

α

)

high sensitive C reactive protein (hs-CRP)

cystatin C (CysC)

malondialdehyde (MDA)

superoxide dismutase (SOD) and oxidized low density lipoprotein (OX-LDL) were detected.

Result:

2

According to the rank test

clinical effect in observation group was better than that in control group (

P

<

0.05). And levels of ABI

TBI and SOD were higher than those in control group (

P

<

0.01). The ameliorate of internal diameter of dorsal artery of foot

peak velocity and blood flow were better than those in control group

and scores of intermittent postscript

lower extremity pain

dorsalis pedis artery pulsation

skin color

skin temperature

numbness of limbs

swelling of extremities and the sign and levels of IL-1

Hcy TNF-

α

hs-CRP

Cys-C and Ox-LDL were lower than those in control group (

P

<

0.01).

Conclusion:

2

Modified Huangqi Guizhi Wuwu Tang can relieve symptoms and signs

lower limb vascular function and hemodynamic

with certain anti-inflammatory effect and oxidative stress. It can also reduce vascular endothelial cell injury

and relieve and postpone the progress of LEAD