Objective:

2

To investigate the dryness effect of

Atractylodes lancea

and

A

.

chinensis

.

Method:

2

Sixty normal and healthy SD rats were randomly divided into 6 groups(10 in each group)

including normal saline group

soybean oil group

low-dose(46.25 mg·kg

-1

·d

-1

) group and high-dose(500 mg·kg

-1

·d

-1

) group of

A

.

lancea

low-dose(46.25 mg·kg

-1

·d

-1

) group and high-dose(500 mg·kg

-1

·d

-1

) group of

A

.

chinensis

the dosing volume was 0.01 mL·g

-1

and the drug was administered orally for 21 days. Taking average daily water intake

submandibular gland tissue

urine volume and expression of aquaporin 2(AQP2) in the kidney

and whole blood viscosity as the evaluation indexes

the dryness effect of long-term administration of equal doses of volatile oil from

A

.

lancea

and volatile oil from

A

.

chinensis

on rats was observed.

Result:

2

Compared with the soybean oil group

long-term administration of high doses of volatile oil from

A

.

lancea

and volatile oil from

A

.

chinensis

could significantly increase average daily water intake

urine volume and whole blood viscosity; decrease the expression of AQP2

and atrophy the acini of submandibular gland

but there was no significant difference between the two groups. Effects of volatile oil from

A

.

lancea

and

A

.

chinensis

with low dose on dryness of rats were not significant.

Conclusion:

2

There is no significant difference between the dryness effect of volatile oil from

A

.

lancea

and

A

.

chinensis

in the same dose. It is proved that the rationality of

A

.

lancea

and

A

.

chinensis

are universal in clinical practice

and this study provides experimental basis for rational use of Atractylodis Rhizoma.