远志-天麻药对治疗癫痫的网络药理学分析

赵泽丰; 陈旭飞; 解景; 李斌; 何希瑞; 郑晓晖

doi:10.13422/j.cnki.syfjx.20191306

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远志-天麻药对治疗癫痫的网络药理学分析

数据挖掘 | 更新时间：2021-02-09

- 远志-天麻药对治疗癫痫的网络药理学分析
- Network Pharmacology of Polygalae Radix and Gastrodiae Rhizoma in Treating Epilepsy
- 中国实验方剂学杂志 2019年25卷第14期页码：207-214
- 作者机构：
  
  1.西北大学　西部资源生物与现代生物技术重点实验室，西安　 710069；
  2.西安交通大学　医学院　附属红会医院，西安　 710054
- 作者简介：
  
  赵泽丰，在读博士，从事中药药物化学研究，E-mail：zzf598155752@sina.com
  郑晓晖，博士生导师，从事中药药物化学研究，E-mail：zhengxh@nwu.edu.cn
- 基金信息：
  
  长江学者和创新团队发展基金滚动项目(IRT_15R55);国家重大仪器设备开发专项(2013YQ17052509);陕西省教育厅科研计划项目(09JS086)
- DOI：10.13422/j.cnki.syfjx.20191306
  中图分类号： R2-0; R22; R285.5
- 收稿日期：2018-10-29，
  
  网络出版日期：2019-03-19，
  
  纸质出版日期：2019-07-20
- 稿件说明：
移动端阅览
赵泽丰, 陈旭飞, 解景, 等. 远志-天麻药对治疗癫痫的网络药理学分析[J]. 中国实验方剂学杂志, 2019,25(14):207-214.

Ze-feng ZHAO, Xu-fei CHEN, Jing XIE, et al. Network Pharmacology of Polygalae Radix and Gastrodiae Rhizoma in Treating Epilepsy[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 207-214.
赵泽丰, 陈旭飞, 解景, 等. 远志-天麻药对治疗癫痫的网络药理学分析[J]. 中国实验方剂学杂志, 2019,25(14):207-214. DOI： 10.13422/j.cnki.syfjx.20191306.

Ze-feng ZHAO, Xu-fei CHEN, Jing XIE, et al. Network Pharmacology of Polygalae Radix and Gastrodiae Rhizoma in Treating Epilepsy[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 207-214. DOI： 10.13422/j.cnki.syfjx.20191306.

摘要

目的：

对远志与天麻进行网络药理学的研究，阐明其药效物质基础，进一步探索其药效成分的潜在靶标。

方法：

基于反向药效团匹配模型分析预测远志与天麻成分的潜在作用靶点，通过生物学信息注释数据库对靶点基因功能及代谢通路进行分析，采用Cytoscape 3.2.1软件构建远志与天麻治疗癫痫的“成分-靶点-通路”网络模型。

结果：

远志中的14种成分与105个靶点具有潜在的相互作用，天麻中的12种成分与109个靶点具有潜在的相互作用。涉及包括癌症通路，神经配体受体相互作用及丝裂原活化蛋白激酶(MAPK)在内的多个生物过程对癫痫起到治疗作用。

结论：

通过与癫痫疾病靶点的关联筛选，并采用分子对接的手段进行验证，得到远志与天麻中的成分可能与单胺氧化酶受体发生相互作用的结论，表明远志与天麻可能通过调控脑内单胺类物质的水平以发挥其抗癫痫功效。预测所得远志与天麻成分靶点与已有文献较接近，表明基于网络药理学的技术手段探讨其抗癫痫作用具有一定的准确性。

Abstract

Objective:

To construct a " drug-target-pathway" network of Polygalae Radix and Gastrodiae Rhizoma in treating epilepsy

in order to explore the " multi-component

multi-target

multi-pathway" mechanism of the two kinds of traditional Chinese medicines.

Method:

According to the reverse pharmacophore matching method

potential targets of Polygalae Radix and Gastrodiae Rhizoma were predicted. Biological information annotation databases were used to analyze the molecular function and biological process of the action targets. Cytoscape 3.2.1 software was used to construct the " ingredient-core

target-pathway" network of Polygalae Radix and Gastrodiae Rhizoma for the treatment of epilepsy.

Result:

The 14 major constituents from Polygalae Radix exhibited interactions with 105 potential targets

and the 12 compounds from Gastrodiae Rhizoma showed interactions with 109 potential targets

involving several cancer signaling pathways

neuroactive ligand-receptor interaction and mitogen-activated protein kinase(MAPK) biological process played roles in the treatment of epilepsy.

Conclusion:

According to the screening for the potential targets relating to epilepsy and the evidences obtaining from docking study

we demonstrated that constituents from Polygalae Radix and Gastrodiae Rhizoma could play an anticonvulsant role by mediating the levels of monoamine substances. The conclusion is close to literatures published online to a certain degree

suggesting the accuracy of the study on the effect of Polygalae Radix and Gastrodiae Rhizoma in treating epilepsy according to the network pharmacology.

关键词

Keywords

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